From: Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care
Species | Model | Dose | Route | Drug protocol | Outcome | Similar efficacy with EPO | Reference |
---|---|---|---|---|---|---|---|
Rat | Cerebral ischemia/reperfusion | 44 μg/kg | IV | On reperfusion | Neuroprotection | Yes | [20] |
Rat | Spinal cord compression | 10 μg/kg | IV | After compression | Neuroprotection | Yes | [20] |
Rat | Sciatic nerve crush | 50 μg/kg | IV | 24 h or 15 minutes pre-treatment, or after nerve crush | Neuroprotection | Yes | [20] |
Rat | Neonatal hypoxia-ischemia | 80 μg/kg | IP | 4 h pre-treatment | Neuroprotection | Yes | [55] |
Rat | Neonatal hypoxia-ischemia | 40 μg/kg | IP | 24 h and 4 h pre-treatment | No protection | Yes | [55] |
Rat | Spinal cord compression | 10 μg/kg | IV | 24 h pre-treatment | Neuroprotection | Yes | [56] |
Mouse | Amyotrophic lateral sclerosis | 32 μg/kg | IP | 3 times per week for 9 weeks | Neuroprotection | Yes | [57] |
Rat | Kainite-induced cell death of primary dissociated anterior horn cultures, in vitro | 2.5 pmol/ml | NA | 72 h pre-treatment | Tissue protection | Yes | [57] |
Mouse | Bi-lateral renal ischemia/reperfusion | 2.5 μg/kg | SC | 30 minutes pre-treatment | Renoprotection | Yes | [21] |
Rat | Contrast-induced nephropathy | 80 μg/kg | IV | 1 h pre-treatment | Renoprotection | Yes | [58] |
NA | Contrast-induced cell death of LLC-PK1 cultures, in vitro | 25 ng/ml | NA | 1 h pre-treatment | Tissue protection | Yes | [58] |
Rat | Intestine ischemia/reperfusion | 5 μg/kg | SC | 10 minutes pre-treatment, 30 minutes into ischemia and on reperfusion | Intestinal protection | Yes | [22] |
Rat | Cerebral ischemia/reperfusion | 20 μg/kg/day | IV infusion | Started on reperfusion for 4 days | Neuroprotection | Yes | [59] |
Mouse | Uni-lateral renal ischemia/reperfusion with diabetes | 15 μg/kg | SC | 30 minutes pre-treatment | Renoprotection | Yes | [60] |
Gerbil | Bi-lateral common carotid artery occlusion | 50 μg/kg | IP | 3 h pre-treatment, on reperfusion and 24 h into reperfusion | Neuroprotection | Yes | [61] |
Mouse | 5/6 nephrectomy with subsequent heart failure | 23 μg/kg | SC | Twice a week for 4 weeks after establishment of renal dysfunction | Cardioprotection | Yes | [62] |
Rat | Lumbar disc herniation | 13.4 μg/kg | SC | 1 day pre-treatment and daily for 2 weeks | Reduced pain related behavior | Yes | [63] |