Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy

Table 3 Main outcome variables

	VAP % (95% CI) no./total no.	No VAP % (95% CI) no./total no.	Relative risk (95% CI)	P value
Outcome
Primary
ICU mortality	41.8 (32.6-51.7) 41/98	30.7 (25.2-36.8) 74/241	1.36 (1.00-1.84)	0.05
Secondary
28-Day mortality	26.5 (18.8-36.0) 26/98	29.0 (23.7-35.1) 70/241	0.91 (0.62-1.34)	0.64
90-Day mortality	41.8 (32.6-51.7) 41/98	33.6 (27.9-39.8) 81/241	1.24 (0.93-1.67)	0.15
Ventilator-free days from day 1 to day 28	0 (0-10)	14 (0-21)		0.0001
Ventilator-free days from day 1 to day 90	50.5 (0-70)	76 (0-83)		0.0001
ICU-free days from day 1 to day 28	0 (0-0)	4 (0-16)		0.0001
ICU-free days from day 1 to day 90	32 (0-62)	66 (0-78)		0.0001
Days without failure of circulatory, coagulation, hepatic, and renal organs from day 1 to day 28	14.3 ± 10.4	14.0 ± 10.8		0.77

±, means ± SD. Differences between groups were assessed by using Student t test, Wilcoxon test, or χ² analysis. The number of ventilator-free days is the mean number of days from day 1 to day 28 or day 90 with spontaneous breathing for at least 48 consecutive hours. CI, 95% confidence interval; NMBA, neuromuscular blocking agent.

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