Early neurovascular uncoupling in the brain during community acquired pneumonia

Table 1 Group data for vascular risk factors, medication, and resting EEG data together with ANOVA statistical results

	Acute pneumonia (A)	Recovery from pneumonia (R)	Control (C)	ANOVA
Age, years	67 ± 13	65 ± 11	66 ± 8	NS
Number	43	24	30	-
Female/male ratio	30/13	17/7	16/14	-
RR mean, mm Hg	83 ± 12	86 ± 12	82 ± 14	NS
Body mass index	24 ± 6	28 ± 6	24 ± 6	NS
Smoker, pack-years	46 ± 8	31 ± 13	-	NS
Diabetes, percentage	17	14	-	NS
Coronary artery disease, percentage	44	29	-	NS
Leukocytes, G/L	11 ± 5	10 ± 4	N.O.	NS
CRP, mg/dL	95 ± 22	23 ± 23	N.O.	P < 0.0001
Temperature,°C	36.7 ± 0.6	36.3 ± 0.3	N.O.	NS
pH	7.37 ± 0.06	7.40 ± 0.03	N.O.	NS
Hkt, percentage	38 ± 6	38 ± 5	N.O.	NS
sO₂ percentage	93 ± 4	96 ± 4	N.O.	P < 0.01
ATS score	2.9 ± 0.8	1.9 ± 0.7	N.O.	P < 0.0001
PSI score	99 ± 27	86 ± 24	N.O.	P < 0.05
CURB-65 score	1.5 ± 0.9	1.3 ± 0.9	N.O.	NS
APACHE II score	13 ± 4	11 ± 4	N.O.	P < 0.05
GCS score	15 ± 0.5	15 ± 0.4	N.O.	NS
ICDSC score	3 ± 1	1 ± 1	N.O.	P < 0.0001
EEG μV² delta	82 ± 71	81 ± 58	98 ± 68	NS
EEG μV² theta	58 ± 62	56 ± 52	26 ± 12	C-A: P < 0.01; C-R: P < 0.01
EEG μV² alpha	118 ± 126	126 ± 98	151 ± 128	NS
EEG μV² beta	40 ± 25	44 ± 24	31 ± 12	NS
EEG percentage delta	30 ± 15	27 ± 13	31 ± 16	NS
EEG percentage theta	19 ± 12	22 ± 11	10 ± 3	C-A: P < 0.001; C-R: P < 0.0001
EEG percentage alpha	35 ± 17	35 ± 13	47 ± 20	C-A: P < 0.01; C-R: P < 0.05
EEG percentage beta	16 ± 7	16 ± 9	12 ± 5	C-A: P < 0.05
EEG peak Hz delta	1.2 ± 0.3	1.2 ± 0.4	1.2 ± 0.3	NS
EEG peak Hz theta	6.6 ± 0.9	7.1 ± 0.7	6 ± 0.8	C-A: P < 0.001; C-R: P < 0.0001 A-R: P < 0.05
EEG peak Hz alpha	9.4 ± 0.9	9.1 ± 0.8	11 ± 0.8	C-A: P < 0.0001; C-R: P < 0.0001
EEG peak Hz beta	15.9 ± 2	15.6 ± 2.1	15.9 ± 2.2	NS

Data are presented as mean ± standard deviation unless otherwise indicated. ANOVA, analysis of variance; APACHE II, Acute Physiology and Chronic Health Evaluation II; ATS, American Thoracic Society Scale; CRP, C-reactive protein; CURB-65, confusion of new onset (defined as an abbreviated mental test score of 8 or less), urea of greater than 7 mmol/L (19 mg/dL), respiratory rate of 30 breaths per minute or greater, systolic blood pressure of less than 90 mm Hg or diastolic blood pressure of 60 mm Hg or less, and age of at least 65 years; EEG, electroencephalogram; GCS, Glasgow Coma Scale; Hkt, hematocrit; ICDSC, Intensive Care Delirium Screening Checklist; N.O., nitric oxide; NS, not significant; PSI, pneumonia severity index; RR, blood pressure; sO₂, blood oxygen saturation.

ISSN: 1364-8535