Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study

Table 3 Risk factors associated with acute organ failure.

Predictor variable	Univariate analysis			Multivariate analysis (n= 108)
	OR¹	95% CI	P -value	OR¹	95% CI¹	P - value^{2, 3}
Age (years)	1.00	0.99 - 1.03	0.339			0.381
APACHE II	1.09	1.02 - 1.17 (n = 120)	0.008	1.08	1.00 - 1.17	0.064
Female gender	1.02	0.47 - 2.23	0.960			0.668
OPR/Theatre admission	0.44	0.20 - 1.01	0.052			0.324
Admission PaO2/FiO2 ratio	0.80	0.58 - 1.00 (n = 114)	0.038			0.498
Hypoxemic failure	4.56	1.98 - 10.53 (n = 120)	< 0.001	5.63	1.95 - 16.26	0.001
Type 2 (ventilatory) failure	0.11	0.01 - 0.86 (n= 120)	0.035			0.208
Positive end-expiratory pressure support (PEEP) only	0.14	0.02 - 1.12 (n = 116)	0.064			0.411
PEEP and positive pressure inspiratory support	8.95	1.12 - 71.42 (n = 116)	0.039	7.00	0.61 - 79.79	0.117
Endotracheal tube	2.76	1.16 - 6.59 (n = 116)	0.022			0.353
Previous statin therapy	1.10	0.98 - 1.24	0.112	1.16	0.99 - 1.35	0.064
Statin on ICU day 1	0.35	0.09 - 1.32 (n = 116)	0.122	0.18	0.03- 1.13	0.068
Admitted with an infection	2.42	1.02 - 5.73	0.044			0.985
Admission lactate	1.06	0.86 - 1.32 (n = 110)	0.579			0.209
Admission white cell count	1.00	0.93 - 1.06 (n = 115)	0.880			0.570
Cardiovascular dysfunction	2.80	1.55 - 5.05	0.001	2.06	1.02 - 4.14	0.044
Renal dysfunction	2.21	1.10 - 4.45	0.026	2.32	0.93 - 5.79	0.070
Hepatic dysfunction	2.67	1.11 - 6.39	0.028			0.248
Haematological dysfunction	1.86	0.87 - 3.99	0.111			0.714

¹OR (odds ratio) per one unit change, as appropriate for each variable. ²Value adjusted for other variables when OR and 95% CI (confidence interval) presented. ³Likelihood ratio value for variable selection when OR and 95% CI not presented. APACHE, acute physiology and chronic health evaluation; ICU, intensive care unit; OPR, operating room; PaO2/FiO2,

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