Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study

Terblanche, Marius; Kruger, Peter; Gangi, Stefania di; Gearay, Sadiq; Gilfeather, Lynn; Ferguson, Niall D; Pearse, Rupert; Beale, Richard; Rhodes, Andrew; Brett, Stephen J; McAuley, Daniel F

doi:10.1186/cc11306

Critical Care

Table 1 Baseline data for eligible patients.

From: Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study

	Cohort, n= 121⁵	Progressed to AOF, n= 45 (37.2%)	No progression to AOF, n= 76 (62.8%)	P-value
Demographic data ¹
Age	56.0 (19.1)	58.1 (19.8)	54.7 (18.7)	0.432
Female gender	40 (33.1)	15 (33.3)	25 (32.9)	1.0
APACHE II	13.8 (6.3), n = 120	15.8 (5.6)	12.5 (6.2), n = 75	0.005
Chronic comorbidities	53 (43.8)	22 (49.0)	31 (40.8)	0.45
Current smoker	23 (19.0), n = 83	12 (26.7), n = 34	11 (14.5), n = 36	0.19
Previous statin therapy	26 (21.5), n = 105	8 (17.8), n = 36	18 (23.7), n = 69	0.23
Admission characteristics ²
Reason for admission:
Respiratory infection	21 (17.4)	10 (22.2)	11 (14.5)	0.277
COPD/Asthma	8 (6.6)	2 (4.4)	6 (7.9)	0.709
Respiratory	31 (25.6)	8 (17.8)	23 (30.3)	0.128
Sepsis & septic shock	7 (5.8)	5 (11.1)	2 (2.6)	0.100
Shock (CVS)	8 (6.6)	5 (11.1)	3 (4.0)	0.146
CVS (other)	4 (3.3)	2 (4.4)	2 (2.6)	0.628
Trauma	17 (14.1)	7 (15.6)	10 (13.2)	0.714
Neurological	4 (3.3)	0 (0.0)	4 (5.3)	0.296
Drug overdose	2 (1.7)	0 (0.0)	2 (2.6)	0.529
Gastrointestinal	18 (14.9)	6 (13.3)	12 (15.8)	0.714
Other	1 (0.8)	0 (0.0)	1 (1.3)	1.000
Admission source
OPR/Theatre	43 (35.5)	11 (24.4)	32 (42.1)	0.050
Hospital floor/ward	30 (24.8)	15 (33.3)	15 (19.7)	0.094
ER/A&E	30 (24.8)	10 (22.2)	20 (26.3)	0.614
Other hospital area	5 (4.1)	2 (4.4)	3 (4.0)	1.000
Another hospital	13 (10.7)	7 (15.6)	6 (7.9)	0.188
Other:
Readmission to ICU	12 (9.9)	4 (8.9)	8 (10.5)	1.0
Admitted with any infection	28 (23.1)	15 (33.3)	13 (17.1)	0.041
Admitted with pneumonia³	21 (75.0)	12 (80.0)	9 (69.2)	0.67
Positive microbiological cultures³	42 (40.4)	17 (43.6)	25 (38.5)	0.606
Organ function - SOFA score ⁴
Respiratory	2 (3)	3(3)	2(3)	0.019
Renal	0 (1)	0(1)	0(0)	0.048
Haematological	0(0)	0(1)	0(0)	0.197
Cardiovascular	1(1)	1(3)	1(1)	0.002
Hepatic	0(0)	0(1)	0(0)	0.016
Neurological	2(4)	3(3)	2(3)	0.016
Total SOFA score	4(4)	5(5)	3(3)	< 0.0001
Total SOFA score excluding respiratory	1(2)	3(4)	1(2)	< 0.0001

¹Mean (SD) or total (%) unless otherwise indicated. ²N, (%). ³Further data available in the online addendum. ⁴Presented as median and interquartile range. ⁵Two patients were discharged soon after admission. AOF, acute organ failure; APACHE, acute physiology and chronic health evaluation; COPD, chronic obstructive pulmonary disease; CVS, cardiovascular; ER/A&E, emergency room/accident & emergency; ICU, intensive care unit; OPR, operating room; SOFA, sequential organ failure assessment.

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ISSN: 1364-8535

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