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Table 2 Common terminology Criteria for Adverse Events Version 4

From: Clinical review: Serious adverse events associated with the use of rituximab - a critical care perspective

Grade of toxicity Brief description
Grade 1 Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
Grade 2 Moderate; minimal, local, or non-invasive intervention indicated; limiting age-appropriate instrumental ADLa
Grade 3 Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADLb
Grade 4 Life-threatening consequences; urgent intervention indicated
Grade 5 Death related to adverse event
  1. a'Instrumental ADL' refers to activities of daily living such as preparing meals, shopping for groceries or clothes, using the telephone, and managing money. b'Self-care ADL' refers to bathing, dressing and undressing, feeding oneself, using the toilet, taking medications, and not being bedridden. From the National Cancer Institute Common Terminology Criteria for Adverse Events v4.0 NCI, NIH, DHHS. May 29, 2009 NIH publication #- 09-7473.