Grade of toxicity | Brief description |
---|---|
Grade 1 | Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated |
Grade 2 | Moderate; minimal, local, or non-invasive intervention indicated; limiting age-appropriate instrumental ADLa |
Grade 3 | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADLb |
Grade 4 | Life-threatening consequences; urgent intervention indicated |
Grade 5 | Death related to adverse event |