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Table 1 Demographic characteristics of patients included in the two study groups

From: Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial

 

Nystatin group (n= 49)

Control group (n= 50)

P value

Age (years)

54 ± 22

58 ± 19

0.27

Female/male

18/31

20/30

0.80

Sequential Organ Failure Assessment score

7 ± 2

7 ± 2

0.69

APACHE II score

19.5 ± 7

19.3 ± 8

0.89

Type of admission

   

   Abdominal surgery

6 (12%)

9 (18%)

0.42

   Neurosurgery

19 (39%)

26 (52%)

0.19

   Trauma

24 (49%)

15 (30%)

0.05

   Duration of hospital stay before ICU admission (days)

2 ± 4

2 ± 4

0.6

Duration of mechanical ventilation (days)

13 ± 11

13 ± 12

0.93

Duration of ICU stay (days)

15 ± 14

15 ± 14

0.86

Risk factors

   

   Diabetes mellitus

13 (26%)

9 (18%)

0.3

   Neutropenia (WBC < 4,000/mm3)

0

0

 

   Steroids (days -7 to 3)

11 (22%)

7 (14%)

0.96

   Multiple transfusions

12 (24%)

13 (26%)

0.86

   Pancreatitis (days -7 to 0)

0

2 (4%)

0.55

   Chronic renal failure

0

1 (2%)

0.31

   Immunosuppressive agents other than steroids (days -7 to 0)

0

0

 

   Dialysis (days 1 to 3)

0

1 (2%)

0.31

   Total parenteral nutrition (days 1 to 3)

29 (59%)

27 (54%)

0.36

   Central venous catheter (days 1 to 3)

49 (100%)

50 (100%)

 

   Antibiotic therapy (days 1 to 3)

40 (81%)

42 (84%)

0.63

   Acute renal failure

0

0

 

Mortality

11 (22%)

13 (26%)

0.68

  1. Data presented as mean ± standard deviation or n (%). Risk factors are recorded as suggested by Ostrosky-Zeichner and colleagues [19]. APACHE, Acute Physiology and Chronic Health Evaluation; WBC, white blood cells.