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Table 1 Demographic characteristics of patients included in the two study groups

From: Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial

  Nystatin group (n= 49) Control group (n= 50) P value
Age (years) 54 ± 22 58 ± 19 0.27
Female/male 18/31 20/30 0.80
Sequential Organ Failure Assessment score 7 ± 2 7 ± 2 0.69
APACHE II score 19.5 ± 7 19.3 ± 8 0.89
Type of admission    
   Abdominal surgery 6 (12%) 9 (18%) 0.42
   Neurosurgery 19 (39%) 26 (52%) 0.19
   Trauma 24 (49%) 15 (30%) 0.05
   Duration of hospital stay before ICU admission (days) 2 ± 4 2 ± 4 0.6
Duration of mechanical ventilation (days) 13 ± 11 13 ± 12 0.93
Duration of ICU stay (days) 15 ± 14 15 ± 14 0.86
Risk factors    
   Diabetes mellitus 13 (26%) 9 (18%) 0.3
   Neutropenia (WBC < 4,000/mm3) 0 0  
   Steroids (days -7 to 3) 11 (22%) 7 (14%) 0.96
   Multiple transfusions 12 (24%) 13 (26%) 0.86
   Pancreatitis (days -7 to 0) 0 2 (4%) 0.55
   Chronic renal failure 0 1 (2%) 0.31
   Immunosuppressive agents other than steroids (days -7 to 0) 0 0  
   Dialysis (days 1 to 3) 0 1 (2%) 0.31
   Total parenteral nutrition (days 1 to 3) 29 (59%) 27 (54%) 0.36
   Central venous catheter (days 1 to 3) 49 (100%) 50 (100%)  
   Antibiotic therapy (days 1 to 3) 40 (81%) 42 (84%) 0.63
   Acute renal failure 0 0  
Mortality 11 (22%) 13 (26%) 0.68
  1. Data presented as mean ± standard deviation or n (%). Risk factors are recorded as suggested by Ostrosky-Zeichner and colleagues [19]. APACHE, Acute Physiology and Chronic Health Evaluation; WBC, white blood cells.