From: Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial
 | Nystatin group (n= 49) | Control group (n= 50) | P value |
---|---|---|---|
Age (years) | 54 ± 22 | 58 ± 19 | 0.27 |
Female/male | 18/31 | 20/30 | 0.80 |
Sequential Organ Failure Assessment score | 7 ± 2 | 7 ± 2 | 0.69 |
APACHE II score | 19.5 ± 7 | 19.3 ± 8 | 0.89 |
Type of admission | Â | Â | Â |
   Abdominal surgery | 6 (12%) | 9 (18%) | 0.42 |
   Neurosurgery | 19 (39%) | 26 (52%) | 0.19 |
   Trauma | 24 (49%) | 15 (30%) | 0.05 |
   Duration of hospital stay before ICU admission (days) | 2 ± 4 | 2 ± 4 | 0.6 |
Duration of mechanical ventilation (days) | 13 ± 11 | 13 ± 12 | 0.93 |
Duration of ICU stay (days) | 15 ± 14 | 15 ± 14 | 0.86 |
Risk factors | Â | Â | Â |
   Diabetes mellitus | 13 (26%) | 9 (18%) | 0.3 |
   Neutropenia (WBC < 4,000/mm3) | 0 | 0 |  |
   Steroids (days -7 to 3) | 11 (22%) | 7 (14%) | 0.96 |
   Multiple transfusions | 12 (24%) | 13 (26%) | 0.86 |
   Pancreatitis (days -7 to 0) | 0 | 2 (4%) | 0.55 |
   Chronic renal failure | 0 | 1 (2%) | 0.31 |
   Immunosuppressive agents other than steroids (days -7 to 0) | 0 | 0 |  |
   Dialysis (days 1 to 3) | 0 | 1 (2%) | 0.31 |
   Total parenteral nutrition (days 1 to 3) | 29 (59%) | 27 (54%) | 0.36 |
   Central venous catheter (days 1 to 3) | 49 (100%) | 50 (100%) |  |
   Antibiotic therapy (days 1 to 3) | 40 (81%) | 42 (84%) | 0.63 |
   Acute renal failure | 0 | 0 |  |
Mortality | 11 (22%) | 13 (26%) | 0.68 |