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Figure 5 | Critical Care

Figure 5

From: GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance

Figure 5

Effect of γ-aminobutyric acid (GABA) on alveolar fluid clearance after ventilator-induced lung injury. Adult female rats were subjected to high-tidal-volume (40 ml/kg BW) ventilation for 60 minutes with and without instillation of GABA (500 μM) and/or bicuculline (200 μM). A 5% bovine serum albumin along with 1 mg/ml FITC-albumin was included in the instillate for estimating alveolar fluid clearance. A decrease in FITC-albumin concentration was then calculated. Shown are the results of the percentage decrease in FITC-albumin concentration after ventilation for 1 hour. Shown are the mean ± SEM (n = 4 to 5 per group). *P < 0.05 versus saline.

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