Table 1 Overview of retrospective studies on the effects of antiplatelet medication in patients with traumatic brain injury
From: Clinical review: Traumatic brain injury in patients receiving antiplatelet medication
Study | Inclusion criteria | Antiplatelet therapy | Number of subjects | Mortality rate | Major findings |
|---|---|---|---|---|---|
Mina et al. 2002 [20] | Posttraumatic ICH | Aspirin | 19 | 47% aspirin group; 8% control group | Mortality significantly increased with aspirin therapy. No difference in mortality rates between aspirin and warfarin treated patients |
Spektor et al. 2003 [23] | Mild and moderate TBI, age >60 years | Aspirin (100 mg/day) | 110 | NR | Aspirin therapy had no effect on incidence of posttraumatic ICH after mild to moderate TBI |
Ohm et al. 2005 [21] | Posttraumatic ICH | Aspirin, clopidogrel | 90 | 23% antiplatelet group; 8% control group | Mortality threefold increased with antiplatelet therapy. GCS <12 and age >76 years risk factors for death in patients on antiplatelet therapy |
Jones et al. 2006 [24] | All TBI, age >50 years | Clopidogrel | 43 | 7% clopidogrel group | Clopidogrel-treated patients have higher rates of cranial surgery and episodes of rebleeds. More blood products were transfused in clopidogrel-treated patients |
Wong et al. 2008 [25] | All TBI | Aspirin, clopidogrel | 111 | 14% clopidogrel group; 3% aspirin group | Clopidogrel-treated patients were more likely to be discharged to long-term inpatient facilities |
Major et al. 2009 [22] | All TBI | Aspirin, clopidogrel | 287 | 1.4% aspirin group | Mortality rate 21% in patients on aspirin with posttraumatic ICH. Three of the four patients who died in the aspirin group deteriorated with a significant delay |
Bonville et al. 2011 [26] | All TBI | Aspirin, clopidogrel | 271 | 12.3% aspirin group; 9.3% clopidogrel group | Use of antiplatelet agents did not affect mortality or length of hospital stay |