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Table 5 Demographic characteristics and laboratory variables of patients with secondary HLH/MAS treated with PE and methylprednisolone or IVIG or with PE and chemotherapy or dexamethasone

From: Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment?

 

PE and methylprednisolone or IVIG (n= 17)

PE and chemotherapy or dexamethasone (n= 6)

 
 

Frequency, percentage

Number

 

Frequency, percentage

Number

 

P

Males/Females

88/12

15/2

 

33/67

2/4

 

0.003

Underlying disease

77

13

 

83

5

 

0.6

Mechanical ventilation

89

15

 

83

5

 

0.5

 

Mean ± SD

Median

Range

Mean ± SD

Median

Range

 

Age, years

6.8 ± 3.3

6.5

2-14

7.6 ± 4.8

6.8

2.8-15.1

0.8

PRISM III-24 score

25.6 ± 13.4

25.6

7-48

19.5 ± 8.8

17.5

11-53

0.3

PELOD score

26.2 ± 13.8

24

4-52

27.5 ± 15.

26.5

13-53

0.9

Number of organs involved

4.5 ± 1

5

3-6

4.6 ± 1

5

3-6

0.7

Hemoglobin, g/dL

7.3 ± 1.5

8

4.8-8.9

8.8 ± 3.3

8.3

5.2-15

0.4

Leukocytes,/mm3

10,145 ± 9,230

6,270

500-26,400

12,096 ± 17189

6,500

400-46,600

0.9

Absolute neutrophil count,/mm3

7,420 ± 7,598

7,420

100-23,300

8,801 ± 13,291

4,475

0-35,000

0.6

Platelet,/mm3

51,594 ± 42,767

45,000

10,000-187,000

80,833 ± 81,052

70,000

12,000-235,000

0.6

PT, seconds

29.2 ± 14.68

25

13-69

14 ± 2.1

14.1

10.3-16.5

0.004

aPTT, seconds

45.2 ± 13.1

45.8

30-74

33.2 ± 14

25.7

24.7-59.3

0.05

Fibrinogen, mg/dL

188.3 ± 169

148.5

0-607

206 ± 139

206

110-443

0.2

Triglycerides, mg/dL

515 ± 275

450

122-1,094

654 ± 507

547

108-1,511

0.9

Albumin, mg/dL

2.6 ± 0.7

2.7

1.4-4.1

2.7 ± 0.3

2.6

2.4-3.3

0.9

Sodium, mEq/L

131 ± 6.9

131

120-141

136 ± 6.7

135

130-147

0.1

LDH, U/L

42,10 ± 3306

2,300

750-11,270

2,349 ± 1,934

2,310

410-4,374

0.4

ALT, U/L

310 ± 627

100

21-2,362

3,080 ± 5,466

409

227-11,276

0.03

Ferritin, μg/dL

20,538 ± 28,199

5,109

765-100,000

38,844 ± 38,130

31,718

2,998-97,767

0.2

MV duration, days

18.7 ± 17.4

12

2-65

20 ± 25

5

1-60

0.6

PICU LOS, days

23 ± 18.8

16

4-69

21.6 ± 23

12.9

1-60

0.5

Hospital LOS, days

43.9 ± 33.7

30

11-110

39.2 ± 26.3

41.5

5-70

0.8

 

Frequency

Number

 

Frequency

Number

  

Survival

100%

17

 

50%

3

 

0.002

  1. ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; HLH, hemophagocytic lymphohistiocytosis; IVIG, intravenous immunoglobulin; LDH, lactate dehydrogenase; LOS, length of stay; MAS, macrophage activation syndrome; MV, mechanical ventilation; PE, plasma exchange; PELOD, Pediatric Logistic Organ Dysfunction; PICU, pediatric intensive care unit; PRISM, Pediatric Risk of Mortality; PT, Prothrombin time; SD, standard deviation.