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Table 4 Demographic characteristics and laboratory variables of survivors and non-survivors

From: Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment?

  Survivors (n= 20) Non-survivors (n= 3)  
  Frequency, percentage Number Frequency, percentage Number P
Females/Males 20/80 4/16 67/33 2/1 0.08
Underlying disease 80 16 67 2 0.6
Mechanical ventilation 85 17 100 3 0.5
  Mean ± SD Median Range Mean ± SD Median Range P
Age, years 6.9 ± 3.3 6.7 2-14 8 ± 6.3 6.2 2.8-15.1 0.7
PRISM III-24 score 25.3 ± 13 21 7-48 14 ± 5.1 14 11-21 0.2
PELOD score 27.2 ± 14.5 25 4-53 22.3 ± 9.1 21 14-32 0.7
Number of organs involved 4.5 ± 1 5 3-6 5 ± 1 5 4-6 0.5
Hemoglobin, g/dL 7.5 ± 1.4 8 4.8-8.9 9.6 ± 4.9 8.8 5.2-15 0.4
Leukocytes,/mm3 8,814 ± 8,836 6,220 400-26,400 19,900 ± 22,981 11,000 2,700-46,000 0.3
Absolute neutrophil count,/mm3 66,688 ± 7,279 4,370 0-23,000 14,816 ± 17,783 8,030 1,450-35,000 0.3
Platelets,/mm3 59,255 ± 57,758 48,000 10,000-235,000 59,000 ± 35,510 79,000 18,000-80,000 0.6
PT, seconds 26.4 ± 14.9 24.9 10.3-69 15.3 ± 1.3 15.3 13.9-16.5 0.2
aPTT, seconds 41.9 ± 14.1 39 24.7-74 41.2 ± 17.2 39.4 25-59 0.5
Fibrinogen, mg/dL 201 ± 162 180 0-607 236 ± 180 156 110-443 0.2
Triglycerides, mg/dL 554 ± 349 436 122-1551 559.5 ± 417 638 108-931 0.7
Albumin, g/dL 2.6 ± 0.6 2.7 1.4-4.1 2.8 ± 0.5 2.6 2.4-3.3 0.8
Sodium, mEq/L 131 ± 6 132 120-141 141 ± 8.5 141 135-147 0.3
ALT, U/L 324 ± 585 128 21-2,362 5,751 ± 7,812 1250 227-11,276 0.14
LDH, U/L 3,884 ± 3146 2300 410-11,270 2,327 ± 2,665 2,327 443-4,212 0.6
Ferritin, μg/dL 20,124 ± 27163 5054 765-100,000 40,802 ± 34,583 40,802 16,348-65,256 0.06
Treatment protocols Frequency Number Frequency Number 0.002
PE and chemotherapy or dexamethasone (protocols 3 and 4) 50% 3/6 50% 3/6  
PE and methylprednisolone or IVIG (protocols 1 and 2) 100% 17/17 None    
  1. ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; IVIG, intravenous immunoglobulin; LDH, lactate dehydrogenase; PE, plasma exchange; PELOD, Pediatric Logistic Organ Dysfunction; PRISM, Pediatric Risk of Mortality; PT, Prothrombin time; SD, standard deviation.