Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment?

Table 3 Laboratory variables of patients with secondary HLH/sepsis/MODS/MAS

Variable	Mean ± SD	Median	Range
Hemoglobin, g/dL	7.8 ± 2.1	8.1	4.8-15.0
Leukocytes,/mm³	10,260 ± 11,402	6,240	400-46,000
Absolute neutrophil count,/mm³	7,796 ± 9,148	5,025	0-35.000
Platelet count,/mm³	59,221 ± 54,733	51,000	10,000-235,000
PT, seconds	24.8 ± 14.3	21.7	10.3-69.0
aPTT, seconds	42.3 ± 14.5	39	24.7-74.2
Fibrinogen, mg/dL	206 ± 161	171	0-607
Triglycerides, mg/dL	555 ± 348	528	108-1,511
Albumin, g/L	2.6 ± 0.6	2.6	1.4-4.1
Sodium, mEq/L	132.2 ± 7.1	132	120-147
Alanine aminotransferase, U/L	962 ± 2,713	135	21-11,276
Lactate dehydrogenase, U/L	3,721 ± 3,071	2,300	765-100,000
Ferritin, μg/dL	25,313 ± 31,246	6,341	765-100,000

aPTT, activated partial thromboplastin time; HLH, hemophagocytic lymphohistiocytosis; MAS, macrophage activation syndrome; MODS, multiple organ dysfunction syndrome; PT, Prothrombin time; SD, standard deviation.

ISSN: 1364-8535