Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment?

Table 2 Diagnostic findings of patients with hyperferritinemia and secondary HLH/sepsis/MODS/MAS

Variable	Secondary HLH/MAS (n= 23), percentage (number)
Fever	100 (23)
Splenomegaly	65 (15)
Cytopenia	96 (22)
Anemia	96 (22)
Thrombocytopenia	91 (21)
Neutropenia	44 (10)
Hypertriglyceridemia	87 (20)
Hypofibrinogenemia	39 (9)
Hyperferritinemia	100 (23)
Hemophagocytosis in bone marrow	100 (23)
Survival	87 (20)

All of the patients met five or more of the criteria required for a diagnosis of hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). HLH, hemophagocytic lymphohistiocytosis; MAS, macrophage activation syndrome; MODS, multiple organ dysfunction syndrome.

ISSN: 1364-8535