Table 1 Basic science research of the role of vitamin D in infection
From: Vitamin D in sepsis: from basic science to clinical impact
Immune response to bacteria |
   • Modulates cytokine profiles and hemostatic parameters in response to bacterial endotoxin (lipopolysaccharide) in rodent models and in vitro experiments of human monocytes and endothelial cells |
   • Involved in the macrophage response to Mycobacterium tuberculosis, bronchial cell response to Pseudomonas aeroginosa, and bladder cell response to Escherichia coli via the antimicrobial peptide cathelicidin |
Immune response to fungi |
   • Modulates cytokine profiles in human monocytes exposed to Candida albicans |
Immune response to virus |
   • Decreases production of inflammatory proteins without increase in viral replication in tracheobronchial cells infected with respiratory syncytial virus |