Replacement of fentanyl infusion by enteral methadone decreases the weaning time from mechanical ventilation: a randomized controlled trial

Table 1 Demographic and clinical characteristics.

Characteristics	MG (n = 37)	CG (n = 31)	P value
Males, number (%)	27 (72)	26 (83)	0.28
Age	43 ± 18	45 ± 17	0.60
Weight	82 ± 16	84 ± 19	0.58
APACHE II	19 ± 8	18 ± 6	0.59
Cause of hospitalization, n (%)
Trauma	17 (45)	14 (45)	0.94
Respiratory	6 (16)	3 (9)	0.42
Sepsis	5 (13)	7 (22)	0.32
Abdominal surgery	5 (13)	2 (6)	0.33
Neurological	3 (8)	3 (9)	0.82
Exogenous intoxication	0	2 (6)	0.11
Cardiac	1 (2)	0	0.35
Fentanyl Initial dose (μg/kg/h)	2.15 ± 1.06	2.35 ± 1.21	0.48
Accumulated dose (μg)	40,608 ± 24,882	41,284 ± 20,545	0.90
Midazolam maleate
Accumulated dose (mg)	1,052 ± 820	1,014 ± 672	0.83
Days on fentanyl before start of weaning	10.1 ± 6	10.4 ± 4.4	0.80
MV days before start of weaning	10.6 ± 6.8	10.3 ± 4.5	0.87
ΔT Hosp. X ICU	3 ± 8	4 ± 12	0.88

Data are presented as n (%) or mean ± standard deviation. ΔT Hosp. X ICU = Time from hospital stay until ICU admission. APACHE, acute physiology and chronic health evaluation; CG, Control group; ICU, intensive care unit; MG, methadone group; MV, mechanical ventilation

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