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Table 1 Demographic and clinical characteristics.

From: Replacement of fentanyl infusion by enteral methadone decreases the weaning time from mechanical ventilation: a randomized controlled trial

Characteristics MG
(n = 37)
CG
(n = 31)
P
value
 
Males, number (%) 27 (72) 26 (83) 0.28  
Age 43 ± 18 45 ± 17 0.60  
Weight 82 ± 16 84 ± 19 0.58  
APACHE II 19 ± 8 18 ± 6 0.59  
Cause of hospitalization, n (%)     
   Trauma 17 (45) 14 (45) 0.94  
   Respiratory 6 (16) 3 (9) 0.42  
   Sepsis 5 (13) 7 (22) 0.32  
   Abdominal surgery 5 (13) 2 (6) 0.33  
   Neurological 3 (8) 3 (9) 0.82  
   Exogenous intoxication 0 2 (6) 0.11  
   Cardiac 1 (2) 0 0.35  
Fentanyl Initial dose (μg/kg/h) 2.15 ± 1.06 2.35 ± 1.21 0.48  
   Accumulated dose (μg) 40,608 ± 24,882 41,284 ± 20,545 0.90  
Midazolam maleate     
   Accumulated dose (mg) 1,052 ± 820 1,014 ± 672 0.83  
Days on fentanyl before start of weaning 10.1 ± 6 10.4 ± 4.4 0.80  
MV days before start of weaning 10.6 ± 6.8 10.3 ± 4.5 0.87  
ΔT Hosp. X ICU 3 ± 8 4 ± 12 0.88  
  1. Data are presented as n (%) or mean ± standard deviation. ΔT Hosp. X ICU = Time from hospital stay until ICU admission. APACHE, acute physiology and chronic health evaluation; CG, Control group; ICU, intensive care unit; MG, methadone group; MV, mechanical ventilation