From: Risk factors for the development of acute lung injury in patients with infectious pneumonia
 | ALI cases n = 112 | Controls n = 112 | Odds ratio | P value |
---|---|---|---|---|
Baseline characteristics | ||||
Age (years) Median (IQR) | 64.5 (53.5-72.0) | 62.0 (53.0-71.5) | 1.00 (0.98-1.03) | 0.65 |
Male gender n (%) | 56 (50) | 61 (55) | 1.43 (0.68-3.3) | 0.52 |
BMI Median (IQR) | 26.7 (24.07-31.05) | 26.4 (21.9-30.4) | 1.00 (0.99-1.01) | 0.48 |
Ever smoker n (%) | 66 (59) | 52 (46) | 1.24 (0.96-1.65) | 0.07 |
Alcohol abuse n (%) | 13 (12) | 9 (8) | 1.28 (0.74-1.93) | 0.37 |
Pneumonia type | Â | Â | Â | 0.007a |
n (%) | Â | Â | Â | Â |
   CAP | 33 (29.5) | 55 (49) | 0.32 (0.15-0.63) |  |
   HCAP | 33 (29.5) | 29 (26) | 1.22 (0.66-2.27) |  |
   HAP | 46 (41) | 28 (25) | 2.10 (1.19-3.86) |  |
Charlson score Median (IQR) | 3 (2-4) | 2 (1-4) | 1.0 (0.88-1.14) | 0.26 |
Aspiration n (%) | 8 (7.1) | 4 (3.6) | 1.84 (0.63-6.55) | 0.25 |
Diabetes n (%) | 25 (22) | 33 (29) | 0.71 (0.39-1.26) | 0.24 |
Immunosuppression n (%) | 52 (46.4) | 50 (44.6) | 1.13 (0.54-2.36) | 0.73 |
Pneumonia severity index score Median (IQR) | 115 (92-142) | 101 (76-119) | 1.02 (1.01-1.03) | < 0.001 a |
Shock n (%) | 47 (42) | 9 (8) | 16.3 (5.47-79.04) | < 0.001 a |
Respiratory rate Median (IQR) | 23 (20-28) | 20 (18-24) | 1.04 (1.00-1.08) | 0.05 |
SaO2/FiO2 Median (IQR) | 236 (107-336) | 336 (247-448) | 0.995 (0.993-0.997 | < 0.001 a |
Bilateral infiltrates n (%) | 61 (54.5) | 31 (38.2) | 3.67 (1.92-7.61) | < 0.001 a |
Pleural effusion n (%) | 23 (20.5) | 17 (15.4) | 1.34 (0.68-2.69) | 0.38 |
Interventions | ||||
Time to antibiotics (hours) Median (IQR) | 0 (0-9) | 0 (0-3) | 1.00 (0.99-1.02) | 0.11 |
Appropriate initial antimicrobial treatment n (%) | 62 (55.4) | 85 (75.9) | 0.29 (0.13-0.58) | < 0.001 a |
Any transfusion n (%) | 38 (33.9) | 15 (13.4) | 4.53 (2.08-11.59) | < 0.001 a |
   Platelets | 15 (13.4) | 4 (3.6) | 6.50 (1.47-59.33) | 0.0098 a |
   Red blood cells | 31 (27.7) | 13 (11.6) | 4.0 (1.59-11.96) | 0.002 a |
   Fresh frozen plasma | 10 (8.9) | 1 (0.9) | - | 0.008 a |
Corticosteroids systemic n (%) | 48 (42.9) | 51 (45.5) | 0.89 (0.51-1.55) | 0.67 |
Mechanical ventilation n (%) | 95 (85) | 24 (21) | 29.4 (10.2-141.17) | < 0.001 a |
Invasive | 80 (71) | 19 (17) | 18.36 (7.24-66.69) | Â |
Noninvasive | 15 (14) | 5 (4) | 2.83 (1.13-8.25) | Â |