From: Pro/con debate: Is etomidate safe in hemodynamically unstable critically ill patients?
Study | N | Intervention | Subjects | Main outcomes |
---|---|---|---|---|
Absalom et al. 1999 [32] | 35 | Etomidate versus thiopentone | ASA III, two or more organ failures | Etomidate may interfere with cortisol synthesis for at least 24 hours |
Schenarts et al. 2001 [33] | 18 | Etomidate versus midazolam | Emergency department patients requiring intubation | CST significantly different at 4 hours, same response at 12 and 24 hours |
Hildreth et al. 2008 [34] | 30 | Etomidate versus midazolam and fentanyl | Trauma patients requiring intubation | Chemical evidence of AI and may have contributed to increased hospital and ICU lengths of stay |
Jabre et al. 2009 [3] | 469 | Etomidate versus ketamine | Emergency department patients requiring intubation | No difference in 28 day morbidity or mortality |
Tekwani et al. 2010 [35] | 122 | Etomidate versus midazolam | Emergency department suspected sepsis requiring intubation | No difference in mean hospital length of stay, ventilator days, ICU stay or in-hospital mortality |
Morel et al. 2011 [36] | 100 | Etomidate versus propofol | Elective cardiac surgery | Etomidate blunts the HPA for more than 24 hours, no associated increase in vasopressor requirements |