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Table 6 Summary of clinical trials on intra-arrest hypothermia (IATH) during cardiac arrest

From: Intra-arrest hypothermia during cardiac arrest: a systematic review

  Setting Method Pts CTRL VF/VT (%) Δt at admission Δt vs CTRL ROSC Hospital admission Survival all patients Survival admitted pts
Callaway [19] OHCA Cranial cooling 22 Y (NT) 41 -0.02°C/min NS IATH 33%
CTRL 0%
IATH 66%
CTRL 15%
IATH 0%
CTRL 0%
IATH 0%
CTRL 0%
Bruel [15] OHCA Cold iv fluids 33 N 24 - 2.1°C NA 61% 61% 12% 20%
Kämärainen [20] OHCA Cold iv fluids 17 N 59 -1.34°C NA 71% 64% 6% 9%
Castrén [16] OHCA Trans-nasal 194 Y (PATH) 30 -1.3°C (tymp) -0.7°C (core)
- 1.3°C (tymp)
IATH 38%
CTRL 43%
IATH 36%
CTRL 42%
IATH 15%
CTRL 13%
IATH 44%
CTRL 31%
Garrett [18] OHCA Cold iv fluids 542 Y (NT) 22 NA NA IATH 37%
CTRL 27%
IATH 28%
CTRL 23%
IATH 13%
CTRL 12%
IATH 44%
CTRL 51%
  1. Δt, difference in temperature; CTRL, control group; iv, intravenous; NA, not applicable/available; N, no; NS, not significant; NT, normothermia; OHCA, out-of-hospital cardiac arrest; PATH, conventional (post-arrest) hypothermia; Pts., patients; ROSC, return of spontaneous circulation; tymp, tympanic; VF, ventricular fibrillation; VT, ventricular tachycardia; Y, yes