Skip to main content

Table 1 Most relevant clinical studies supporting the use of novel strategies to prevent ventilator-associated pneumonia (VAP)

From: Novel preventive strategies for ventilator-associated pneumonia

First Author [ref] Journal, Year Implemented strategy Summary
Morris [3] Crit Care Med, 2011 VAP bundle Before-and-after study, showing that implementation of a 4 item bundle (head elevation, oral chlorhexidine gel, sedation interruptions and a ventilator weaning protocol) reduced VAP rate
Terragni [6] JAMA, 2010 Tracheostomy Randomized trial showing that VAP incidence was not significantly different comparing early (7 days after intubation) to late (14 days) tracheostomy
Nseir [20] Am J Respir Crit Care Med, 2011 Control of ETT cuff pressure Randomized trial showing VAP rate reduction using a pneumatic device to maintain ETT cuff inflating pressure constant
Lacherade [22] Am J Respir Crit Care Med, 2010 Intermittent SSD system Randomized trial; the use of a SSD system resulted in a significant reduction of VAP incidence, including late-onset VAP
Kollef [27] JAMA, 2008 Silver coated ETT Randomized trial showing that VAP rates were lower with silver coated ETTs, as compared to standard ETTs
Miller [33] J Crit Care, 2011 Polyurethane ETT cuff Retrospective assessment of VAP rate with polyurethane vs. PVC cuffed ETTs, favoring the use of polyurethane ETT cuff
Siempos [44] Crit Care Med, 2010 Probiotics Meta-analysis of randomized controlled trials showing an association between the use of probiotics and reduced VAP incidence
  1. ETT, endotracheal tube; SSD, subglottic secretion drainage.