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Table 1 Clinical characteristics and respiratory variables of the patients within 12 hours before study entrya

From: Negative- versus positive-pressure ventilation in intubated patients with acute respiratory distress syndrome

  Cause of lung injury Demographics Respiratory variables   
Patient Disorders predisposing to ARDS Underlying disease SAPS II Body mass index PaO2/FiO2 ratio Plateau pressure (cmH2O) PEEP (cmH2O) FiO2 PaCO2 (mmHg) pH Days on ventilator Outcomes
1 Aspiration Brain injury 34 29.3 152 26 9 0.4 41 7.39 16 Deceased
2 Severe pulmonary thromboembolism and thrombectomy Parkinson's disease 33 25.7 190 32 10 0.4 46 7.40 3 Survived
3 Sepsis, liver failure after valproate administration Endometritis, epilepsy 35 31.1 153 30 14 0.5 45 7.43 5 Survived
4 Aspiration Subarachnoid haemorrhage 33 27.6 190 28 9 0.5 44 7.48 3 Deceased
5 Aspiration Gastric ulcer perforation 34 29.9 153 36 13 0.6 49 7.32 2 Survived
6 Sepsis, aspiration Colon diverticulitis 42 30.4 118 46 22 0.8 65 7.30 47 Deceased
Mean ± SD    35 ± 3 29 ± 2 159 ± 27 33 ± 7 13 ± 5 0.5 ± 02 48 ± 9 7.39 ± 0.07 18 ± 11  
  1. aPatient 2 developed ARDS after embolectomy and three days of mechanical ventilation at pulmonary artery wedge pressures below 18 mmHg. Patient 6 developed ARDS already at admission due to a combination of sepsis after bowel suture insufficiency and aspiration and was treated with lung-protective ventilation already for 47 days at study entry. ARDS, acute respiratory distress syndrome; FiO2, fraction of inspired oxygen pressure; PaCO2, arterial carbon dioxide pressure; PaO2/FiO2, arterial oxygen-to-fraction of inspired oxygen pressure ratio; PEEP, positive end-expiratory pressure; SAPS II, Simplified Acute Physiology Score II [15].