Table 4 Univariate and multivariate analyses for renal dysfunction and renal replacement therapy
Renal dysfunction | Univariate analysis | Multivariate analysis | RRT | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|---|---|
No ( n = 237) | Yes ( n = 117) | P | Renal dysfunction OR - IC 95% | No RRT N = 298 | RRT N = 90 | P | RRT | |
Age (mean ± SD)(year) | 63 ± 16 | 67 ± 14 | 0.03 | 63 ± 16 | 68 ± 15 | 0.03 | ||
Female (n, %) | 86 (36) | 29 (25) | 1 | 108 (36) | 23 (25) | |||
Male (n, %) | 151 (64) | 88 (75) | 0.03 | 2 [1.15 to 3.49] | 190 (64) | 67 (75) | 0.04 | |
SAPS II at admission (median with interquartile) | 42 [35-52] | 49 [40-61] | < 0.01 | 1.03 [1.01 to 1.05] per unit | 43 [35 to 53] | 50 [40 to 63] | < 0.01 | |
Type of admission | 1 | |||||||
Medical | 171 (72) | 67 (57) | 3.49 [1.01-12.07] | 200 (67) | 57 (63) | |||
Elective surgery | 6 (3) | 7 (6) | 1.94 [1.13-3.35] | 13 (4) | 3 (3) | |||
Emergency surgery | 60 (25) | 43 (37) | 0.01 | 85 (29) | 30 (33) | 0.68 | ||
Fluid type (n, %) | ||||||||
None | 5 (2) | 2 (1) | 0.24 | 7 (2) | 2 (2) | 0.89 | ||
Crystalloids | 46 (19) | 14 (12) | 49 (17) | 14 (16) | ||||
Colloids | 19 (8) | 14 (12) | 28 (9) | 11 (12) | ||||
both | 166 (70) | 87 (74) | 214 (72) | 63 (70) | ||||
Use of colloids (n, %) | 185 (78) | 101 (86) | 0.07 | 241 (81) | 74 (82) | 0.82 | ||
Transfusion (n, %) | ||||||||
YES | 47(20) | 32 (28) | 0.07 | 70 (23) | 25 (26) | 0.49 | ||
NO | 190 (80) | 82 (72) | 228 (77) | 65 (72) | ||||
Vasopressors (n, %) | ||||||||
YES | 175 (74) | 106 (91) | < 0.01 | 225 (76) | 82 (91) | < 0.01 | 1 | |
NO | 62 (26) | 11 (9) | 73 (25) | 8 (9) | 2.61 [1.18 to 5.77] | |||
Inotropic drug (n, %) | ||||||||
YES | 39 (16) | 30 (26) | 0.04 | 49 (16) | 22 (24) | 0.09 | ||
NO | 198 (84) | 87 (74) | 249 (84) | 68 (76) | ||||
Decrease in SOFA between H 0 and H 24 (n, %) | ||||||||
YES | 88 (37) | 27 (23) | 1 | 191 (64) | 66 (73) | |||
NO | 149 (63) | 90 (77) | < 0.01 | 2.49 [1.40-4.41] | 107 (36) | 24 (27) | 0.11 | |
Baseline mean arterial pressure (mean ± SD) (mm Hg) | 69 ± 22 | 69 ± 20 | 0.52 | 69 ± 22 | 69 ± 21 | 0.57 | ||
Baseline central venous pressure (mean ± SD) (mm Hg)(MD = 264) | 12 ± 5 | 12 ± 5 | 0.78 | 12 ± 5 | 12 ± 5 | 0.99 | ||
Baseline arterial lactate (mean ± SD) (mMol/l)(MD = 162) | 3.4 ± 2.7 | 3.6 ± 2.8 | 0.68 | 3.4 ± 2.7 | 3.6 ± 3.0 | 0.99 | ||
History of renal dysfunction (n, %) | ||||||||
YES | 11 (5) | 3 (3) | 0.40 | 12 (4) | 3 (3) | 1.00 | ||
NO | 226 (95) | 114 (97) | 86 (96) | 87 (97) | ||||
Baseline creatinine (mean ± SD) (mMol/l) | 122 ± 71 | 148 ± 84 | < 0.01 | 119 ± 69 | 159 ± 87 | < 0.01 | 1.006 [1.003-1.009] per unit | |
Baseline renal SOFA (n, %) | < 0.01 | < 0.01 | ||||||
0 to 1 | 174 (73) | 69 (59) | 218 (73) | 51 (57) | ||||
2-3 to 4 | 63 (27) | 48 (41) | 79 (27) | 39 (43) | ||||
Period of study | ||||||||
Observational | 130 (55) | 52 (44) | 0.06 | 1 | 158 (53) | 44 (49) | 0.49 | |
Interventional | 107 (45) | 65 (56) | 1.90 [1.14-3.18] | 140 (47) | 46 (51) | |||