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Table 4 Multivariate logistic analysis for 28-day mortality

From: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study

  Patients with sepsis
(N= 606)
Patients without sepsis
(N= 819)
  Adjusted odds ratio
(95% CI)
P -value Adjusted odds ratio
(95% CI)
P -value
Age (y.o., IQR) 1.01 (0.99, 1.02) 0.32 1.01 (0.98, 1.04) 0.39
APACHE (IQR) 1.09 (1.05, 1.12) < 0.001 1.19 (1.12, 1.27) < 0.001
Postoperative admission n (%) 0.81 (0.36, 1.85) 0.62 0.56 (0.24, 1.29) 0.17
Mechanical ventilation requirement n (%) 1.72 (1.01, 2.94) 0.045 3.85 (1.40, 10.6) 0.01
Cardiac or vascular diseases 0.87 (0.43, 1.76) 0.70 1.03 (0.38, 2.75) 0.96
Thoracic or respiratory diseases 1.71 (0.99, 2.94) 0.053 1.87 (0.70, 4.97) 0.21
Max. body temp. during ICU stay     
37.5°C to 38.4°C (vs. 36.5°C to 37.4°C) 0.45 (0.24, 0.85) 0.014 1.61 (0.56, 4.68) 0.38
38.5°C to 39.4°C (vs. 36.5°C to 37.4°C) 0.52 (0.24, 1.1) 0.09 3.34 (0.88, 12.69) 0.08
≥ 39.5°C (vs. 36.5°C -37.4°C) 0.47 (0.19, 1.18) 0.11 8.14 (1.67, 39.59) 0.01
NSAIDs 2.61 (1.11, 6.11) 0.028 0.22 (0.03, 1.74) 0.15
Acetaminophen 2.05 (1.19, 3.55) 0.01 0.58 (0.06, 5.26) 0.63
Cooling 1.2 (0.70, 2.05) 0.50 0.71 (0.30, 1.69) 0.44
  1. APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidential interval; MAXICU, maximum body temperature during an ICU stay; NSAIDs, non-steroidal anti-inflammatory drugs
  2. Subgroup with MAXICU < 36.5°C was excluded from this analysis because only three patients with sepsis and none without fell within this temperature range.