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Table 3 Comparison of baseline characteristics and antipyretic treatments of survivors and non-survivors

From: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study

  Patients with sepsis Patients without sepsis
  Survivors
( N = 471)
Non-survivors
( N = 135)
P -value Survivors
( N = 783)
Non-survivors
( N = 36)
P -value
Gender (male) n (%) 291 (61.8%) 94 (69.6%) 0.10 485 (61.9%) 23 (63.9%) 0.81
Age (y.o., IQR) 67 (54, 75) 69 (58, 78) 0.08 64 (54, 73) 74.5 (59, 81.5) 0.003
APACHE (IQR) 20 (16, 24) 24 (21, 28) < 0.001 13 (10, 18) 24 (19.5, 28) < 0.001
Postoperative admission n (%) 59 (12.5%) 9 (6.7%) 0.057 523 (66.8%) 11 (30.6%) < 0.001
Mechanical ventilation requirement n (%) 317 (67.3%) 112 (83.0%) < 0.001 498 (63.6%) 30 (83.3%) 0.016
Reasons for admission n (%)       
   Cardiac or vascular diseases 93 (19.7%) 16 (11.9%) 0.04 422 (53.9%) 13 (36.1%) 0.04
   Thoracic or respiratory diseases 253 (53.7%) 90 (66.7%) 0.007 193 (24.6%) 12 (33.3%) 0.24
   Renal or metabolic disease 48 (10.2%) 13 (9.6%) 0.85 51 (6.5%) 3 (8.3%) 0.67
   Gastrointestinal tract diseases 56 (11.9%) 12 (8.9%) 0.33 102 (13%) 6 (16.7%) 0.53
   Other 21 (4.5%) 4 (3%) 0.44 15 (1.9%) 2 (5.6%) 0.13
Length of stay in ICU 8 (5, 14) 9 (5, 15) 0.74 5 (4, 7) 5 (4, 9) 0.11
NSAIDs       
Number of patients n (%)
(Un adjusted odds ratio (95% CI))
19 (4%) 12 (8.9%) 0.02 98 (12.5%) 1 (2.8%) 0.08
  (2.32 (1.10, 4.91))   (0.20 (0.03, 1.47))  
   Delta body temperature* (°C, IQR) -0.4 (-0.9, -0.1) -0.1 (-0.6, 0.0) 0.08 -0.4 (-0.7, 0) 0.0 (0.0, 0.0) 0.30
Acetaminophen n (%)       
Number of patients n (%)
(Un adjusted odds ratio (95%CI))
75 (15.9%) 41 (30.4%) 0.002 31 (4%) 1 (2.8%) 0.72
  (2.30 (1.48, 3.58))   (0.69 (0.09, 5.23))  
   Delta body temperature* (°C, IQR) -0.4 (-1.1, -0.1) -0.4 (-0.9, -0.2) 0.94 -0.3 (-0.7, 0.0) -0.9 (-0.9, -0.9) 0.28
Cooling n (%)       
Number of patients n (%)
(Unadjusted odds ratio (95%CI))
223 (47.3%) 64 (47.4%) 0.99 366 (46.7%) 18 (50%) 0.74
  (1.00 (0.68, 1.46))   (1.14 (0.58, 2.22))  
   Delta body temperature* (°C, IQR) -0.2 (-0.4, 0) -0.2 (-0.5, 0) 0.55 -0.1 (-0.3, 0) -0.1 (-0.4, 0) 0.16
  1. APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidential interval; IQR, 25%, 75% interquartile; NSAIDs, non-steroid anti-inflammatory drugs
  2. *, Delta body temperature from application of antipyretic to next temperature monitoring