Arginine metabolism is markedly impaired in polymicrobial infected mice

Table 1 Metabolites from plasma samples of healthy and polymicrobial infected mice

Metabolite	Healthy controls	6 hours post sepsis	24 hours post sepsis
Arginine (μM)	101.97 ± 8.12	78.25 ± 5.10	43.65 ± 10.06 ^†‡
Proline (μM)	65.00 ± 4.98	34.79 ± 3.89 ^†	29.99 ± 5.18 ^†
Ornithine (μM)	55.84 ± 3.41	30.04 ± 3.63 ^†	28.31 ± 4.64 ^†
Putrescine (μM)	0.40 ± 0.03	0.19 ± 0.06	4.51 ± 1.81* ^‡
Urea (mg/dl)	28.08 ± 1.57	36.42 ± 2.09	55.61 ± 7.05* ^‡
Glutamine (μM)	590.40 ± 118.91	635.30 ± 107.15	548.50 ± 105.21
Citrulline (μM)	47.67 ± 3.56	45.79 ± 7.18	50.16 ± 4.96
Acetylornithine (μM)	2.48 ± 0.15	2.65 ± 0.33	2.08 ± 0.12
Glutamic acid (μM)	18.68 ± 3.33	14.04 ± 4.30	34.38 ± 11.64
Spermidine (μM)	0.49 ± 0.02	0.43 ± 0.06	0.08 ± 0.05 ^†‡

Data presented as mean ± standard error of the mean. Investigated metabolites from plasma samples of healthy controls (n = 10) and of polymicrobial infected mice 6 hours (n = 10) and 24 hours (n = 10) post sepsis induction. Statistical analysis by one-way analysis of variance (ANOVA) and post-hoc tests using the Scheffé procedure. *Statistically significant difference compared with healthy controls (P ≤ 0.05; ANOVA). ^†Statistically significant difference compared with healthy controls (P ≤ 0.001; ANOVA). ^‡Statistically significant difference between 6 hours and 24 hours post sepsis induction (P ≤ 0.05; ANOVA). Significant data are indicated in bold.

ISSN: 1364-8535