Impact of renal dysfunction on weaning from prolonged mechanical ventilation

Table 1 Comparison of demographics and selected measurements in PMV patients with and without renal dysfunction

	With renal dysfunction	without renal dysfunction	P
	(study group; n = 63)	(control group; n =1014)
Days of mechanical ventilation prior to transfer	42 (6-170)	33 (0-395)	0.04
Gender (% female) 53.1%	56.6%	0.61
Age	69.7 ± 11.3	69.1 ± 12.8	0.96
Serum albumin (g/dl)	2.72 ± 0.53	2.61 ± 0.60	0.06
Creatinine (mg/dl)	4.36 ± 1.69	0.86 ± 0.45	< 0.001
BUN (mg/dl)	78.6 ± 29.1	26.6 ± 18.2	< 0.001
COPD as primary reason for PMV	12.7%	24.5%	0.015
PaCO₂	39.4 ± 9.4	46.9 ± 12.2	< 0.001
P(A-a)O₂ (mmHg)	107.7 ± 58.0	120.4 ± 74.2	0.26
pH	7.41 ± 0.07	7.43 ± 0.07	0.09

BUN = blood urea nitrogen; COPD = chronic obstructive pulmonary disease; PMV = prolonged mechanical ventilation; PaCO₂ = partial pressure of arterial carbon dioxide; P(A-a)O₂ = alveolar-arterial pressure difference.

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