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Table 2 Number of patients who received adequate initial empiric antimicrobials in the DE and NDE groupsa

From: Early use of imipenem/cilastatin and vancomycin followed by de-escalation versus conventional antimicrobials without de-escalation for patients with hospital-acquired pneumonia in a medical ICU: a randomized clinical trial

Organism DE NDE Total P b
  n/m (%) n/m (%) n/m (%)  
All patients 22/29 (75.9) 12/25 (48) 34/54 (63) 0.035
Gram-positive organisms 21/21 (100) 2/14 (14.3) 22/35 (65.7) < 0.001
Gram-negative organisms 9/14 (64.3) 12/14 (85.7) 21/28 (75) 0.190
  1. Values given as number (percentage) of patients. DE, de-escalation group; m, number of patients with isolated organisms; n, number of patients with adequate initial antimicrobial treatment; NDE, non-de-escalation group. aOnly culture-positive patients were included. bWith χ2or the Fisher Exact test.