Table 7 Extracorporeal liver support system
| Â | Technique |
|---|---|
Artificial (Non-cell based) | Â |
Removal of protein-bound toxins by circulating blood over a sorbent material | |
Hybrid process in which blood is passed through a hemodialyzer containing a suspension of sorbent material, such as charcoal or resin, in the extracapillary space | |
Exchange of plasma volume | |
Plasmapheresis [110] | Plasma is separated from the cellular blood components and replaced with normal plasma constituents, allowing the removal of circulating toxins and waste products. |
Removes a specific plasma fraction containing substances within a specific molecular weight. | |
Albumin dialysis | Albumin containing dialysate using an anion exchange resin and active charcoal adsorption allowing albumin-bound toxins in the blood to cross the membrane and bind to the albumin. Water soluble toxins are dialyzed from the albumin circuit by a standard hemodialysis or continuous renal replacement therapy (CRRT) machine. |
   • Single Pass Albumin Dialysis (SPAD) 118-121] |  |
| Â | |
   • Molecular Adsorbent Recirculating System (MARS) [125–131] |  |
| Â | |
Porcine | Â |
• HepatAssist • Bioartificial Liver Support System (BLSS) • Modular Extracorporeal Liver Support (MELS) • Hybrid-Bioartificial Liver (HBAL) • Radial Flow Bioreactor (RFB) • TECA-Hybrid Artificial Liver Support System • AMC-Bioartificial Liver |  |
Human | Â |
• Extracorporeal Liver Assist Device (ELAD) |  |