Bench-to-bedside review: Neonatal sepsis - redox processes in pathogenesis

Table 1 The capacity of neonatal versus`

			Group
Cell type	Stimulus	Parameter	Neonate	Adult	Reference
Bovine polymorphonuclear leukocytes	PMA	^·O₂^-/10⁶ cells/5 minutes (nmol)	5.7 ± 0.8	9.6 ± 2.1 (P < 0.01)	[93]
Human neutrophils	fMPL	Relative production of ^·O₂^- per minute	8.0 ± 3.6	10.6 ± 2.1 (P < 0.05)	[94]^a
Human neutrophils	PMA	Relative production of ^·O₂^- per minute	15.3 ± 6.8	27.5 ± 4.8 (P < 0.01)	[94]^a
Human granulocytes	fMPL	Maximal ROS production in arbitrary units	24 ± 6	57 ± 8 (P < 0.01)	[95]
Human alveolar macrophages	PMA	Intracellular ^·O₂^- production (pmol/3 × 10⁵ cells)	26 ± 6	94 ± 22 (P < 0.05)	[96]
Human alveolar macrophages	Opsonized zymosan	Intracellular ·O₂^- production (pmol/3 × 10⁵ cells)	50 ± 16	164 ± 22 (P < 0.05)	[96]
Human mononuclear phagocytes	IFN-γ	^·O₂^- release (nmol/10⁶ cells)	20 ± 4	31 ± 5 (P < 0.01)	[97]

^aWe extracted and pooled the results provided in the manuscript and performed statistical analysis using Statistica 6.0 (StatSoft, Inc., Tulsa, OK, USA); statistical significance was determined by the means of non-parametric two-tailed Mann-Whitney test. fMPL, N-formyl-methionyl-leucyl-phenylalanin (degradation product of bacterial proteins); IFN, interferon; ^·O₂^-, superoxide; PMA, phorbol 12-myristate 13-acetate; ROS, reactive oxygen species.

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