Skip to main content

Advertisement

Table 1 The capacity of neonatal versus`

From: Bench-to-bedside review: Neonatal sepsis - redox processes in pathogenesis

    Group  
Cell type Stimulus Parameter Neonate Adult Reference
Bovine polymorphonuclear leukocytes PMA ·O2-/106 cells/5 minutes (nmol) 5.7 ± 0.8 9.6 ± 2.1 (P < 0.01) [93]
Human neutrophils fMPL Relative production of ·O2- per minute 8.0 ± 3.6 10.6 ± 2.1 (P < 0.05) [94]a
Human neutrophils PMA Relative production of ·O2- per minute 15.3 ± 6.8 27.5 ± 4.8 (P < 0.01) [94]a
Human granulocytes fMPL Maximal ROS production in arbitrary units 24 ± 6 57 ± 8 (P < 0.01) [95]
Human alveolar macrophages PMA Intracellular ·O2- production (pmol/3 × 105 cells) 26 ± 6 94 ± 22 (P < 0.05) [96]
Human alveolar macrophages Opsonized zymosan Intracellular ·O2- production (pmol/3 × 105 cells) 50 ± 16 164 ± 22 (P < 0.05) [96]
Human mononuclear phagocytes IFN-γ ·O2- release (nmol/106 cells) 20 ± 4 31 ± 5 (P < 0.01) [97]
  1. aWe extracted and pooled the results provided in the manuscript and performed statistical analysis using Statistica 6.0 (StatSoft, Inc., Tulsa, OK, USA); statistical significance was determined by the means of non-parametric two-tailed Mann-Whitney test. fMPL, N-formyl-methionyl-leucyl-phenylalanin (degradation product of bacterial proteins); IFN, interferon; ·O2-, superoxide; PMA, phorbol 12-myristate 13-acetate; ROS, reactive oxygen species.