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Table 3 Comparison of regional citrate anticoagulation versus anticoagulation-free MARS

From: A prospective randomized open-label crossover trial of regional citrate anticoagulation vs. anticoagulation free liver dialysis by the Molecular Adsorbents Recirculating System

 

Citrate

No anticoagulation

P

Primary endpoint

   

   Completed sessions

14/14

9/13

0.04

Secondary endpoints

   

   Clotting score dialyzer (n)

  

0.009

Clean, white

2

2

 

White, limited fibrin deposits, head of dialyzer

7

3

 

White, fibrin deposits head and body dialyzer

5

5

 

Completely clotted, rinse back successful

0

1

 

Completely clotted, rinse back unsuccessful

0

2

 

   Platelets (x 103/mm3)

   

Start of treatment

112 (58 - 146)

92 (67 - 169)

0.6

End of treatment

85 (67 - 162)

89 (60 - 117)

0.7

Reduction of platelets (P intra-group)

12 (P 0.08)

28 (P 0.0005)

0.03

   aPTT (s)

   

Start of treatment

44.1 (40.5 - 57.2)

57.8 (40.7 - 75.4)

0.5

End of treatment

48.0 (41.3 - 61.5)

52.5 (40.0 - 65.7)

0.6

   PT (s)

   

Start of treatment

14.2 (13.8 - 16.0)

17.2 (14.6 - 22.0)

0.1

End of treatment

14.5 (14.0 - 16.2)

16.1 (13.8 - 18.3)

0.4

   TAT complex (μg/L)

   

End of treatment

9.9 (7.7 - 91.7)

25.7 (19.5 - 40.5)

0.3

Increase during treatment

6.1 (5.1 - 50.1)

25.1 (16.8 - 40.5)

0.09

   Treatment efficacy, all sessions

   

Urea reduction ratio

0.51 (0.14)

0.40 (0.14)

0.06

Creatinine reduction ratio

0.40 (0.13)

0.31 (0.17)

0.10

Bilirubin (total) reduction ratio

0.25 (0.09)

0.15 (0.10)

0.02

Bile acids reduction ratio

0.47 (0.20)

0.42 (0.16)

0.34

   Treatment efficacy, completed sessions

   

Urea reduction ratio

0.51 (0.14)

0.46 (0.12)

0.4

Creatinine reduction ratio

0.40 (0.13)

0.40 (0.14)

0.9

Bilirubin (total) reduction ratio

0.25 (0.09)

0.18 (0.09)

0.1

Bile acids reduction ratio

0.47 (0.20)

0.46 (0.21)

0.9

  1. aPTT (S), activated partial thromboplastin time (S); MARS, Molecular Adsorbents Recirculation System; PT, prothrombin time (S); TAT complex, thrombin antithrombin complex.