Parameters of citrate anticoagulation. (a) Extracorporeal ionized calcium concentrations (mmol·l-1) at the MARS dialyzer inlet during regional citrate anticoagulation. (b) Systemic ionized calcium concentrations (mmol·l-1) in patients with regional citrate anticoagulation (closed circles) and in patients receiving MARS treatment without additional anticoagulation (closed cubes). (c) Systemic pH in patients treated with regional citrate anticoagulation. MARS, Molecular Adsorbents Recirculation System.