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Table 5 Kinetic parameters

From: Low doses of esmolol and phenylephrine act as diuretics during intravenous anesthesia

Estimated parameters

Controls

(n= 20)

Esmolol

(n= 20)

Phenylephrine

(n= 20)

Kruskal-

Wallis test

Vc, L

1.5 (1.1-1.8)

1.7 (1.2-2.1)

1.6 (1.2-1.8)

NS

k12, 10-3/minute

28 (21-48)

22 (18-34)

18 (14-31)

NS

k21, 10-3/minute

11 (4-23)

7 (2-17)

4 (0-11)

P < 0.05

k10, 10-3/minute

2.1 (0.9-4.2)

4.2 (2.7-8.3)

4.7 (3.3-10.0)

P < 0.02

  1. Data are the median (25th to 75th percentile) for the group during the entire experiment (0 to 180 minutes). k10, rate constant for fluid leaving the system; k12, rate constant for fluid passing from vc to vt; k21, rate constant for fluid passing from vt to vc; NS, not significant; vc, size of central body fluid space during fluid therapy; Vc, size of central body fluid space at baseline; vt, size of peripheral body fluid space during fluid therapy.