Figure 5
From: Low doses of esmolol and phenylephrine act as diuretics during intravenous anesthesia
Simulated volume-time curves for the central ( V c ) and peripheral ( V t ) fluid spaces and urinary excretion. Thin lines are simulations based on k12, k21, and k10 from each operation, and thick lines are the median for each group. The points in the lower panel are the measured urinary excretion (median values). k10, rate constant for fluid leaving the system; k12, rate constant for fluid passing from vc to vt; k21, rate constant for fluid passing from vt to vc; vc, size of central body fluid space during fluid therapy; Vc, size of central body fluid space at baseline; vt, size of peripheral body fluid space during fluid therapy; Vt, size of peripheral body fluid space at baseline.