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Table 4 Renal perfusion and function

From: Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study

   6% HES 130 10% HES 200 RAc 4% gelatin SHAM
Left renal artery flow, ml/kgBW/min Baseline 7.0 ± 2.9 7.5 ± 2.9 6.1 ± 2.2 6.8 ± 0.4 8.3 ± 3.7
  Before sepsis 5.3 ± 3.8 6.8 ± 2.6 4.6 ± 1.5 6.4 ± 0.5 8.9 ± 5.0
  12 h after sepsis 9.6 ± 3.7 4.0 ± 3.1 5.0 ± 1.9 6.7 ± 2.0 11.4 ± 8.3
Crea as percentage of baseline, % Baseline - - - - -
  Before sepsis 4 ± 5 12 ± 5 ‡ 10 ± 6 14 ± 6 ‡ -2 ± 2
  12 h after sepsis -13 ± 7 87 ± 84**; + -4 ± 13 26 ± 13 -4 ± 13
Crea clearance, ml/min Baseline 136 ± 24 130 ± 87 108 ± 94 101 ± 46 117 ± 13
  Before sepsis 98 ± 47 57 ± 36 57 ± 51 48 ± 17 78 ± 10
  12 h after sepsis 97 ± 15 13 ± 14 * 76 ± 23 38 ± 8 ‡; + 98 ± 48
Urine output, ml/kgBW/h Baseline - - - - -
  Before sepsis - - - - -
  12 h after sepsis 3.3 ± 1.3 0.5 ± 0.3 11.5 ± 12.3 1.1 ± 0.2 2.2 ± 1.9
Cl, mmol/l Baseline 100 ± 1 100 ± 2 99 ± 2 100 ± 2 100 ± 1
  Before sepsis 100 ± 1 103 ± 2 100 ± 1 98 ± 2 101 ± 2
  12 h after sepsis 103 ± 2 111 ± 2 109 ± 9 98 ± 2 **; ║ 101 ± 2
Na, mmol/l Baseline 135 ± 1 135 ± 2 136 ± 2 136 ± 1 136 ± 1
  Before sepsis 136 ± 2 138 ± 2 137 ± 3 138 ± 2 137 ± 1
  12 h after sepsis 136 ± 2 140 ± 3 144 ± 11 138 ± 3 136 ± 2
K + , mmol/l Baseline 4.5 ± 0.4 4.4 ± 0.3 4.5 ± 0.2 4.4 ± 0.1 4.4 ± 0.2
  Before sepsis 3.7 ± 0.2 3.8 ± 0.3 4.0 ± 0.2 3.9 ± 0.2 4.4 ± 0.1
  12 h after sepsis 3.9 ± 0.5 5.6 ± 1.7 4.0 ± 0.3 4.9 ± 1.1 3.8 ± 0.1
Aniongap mmol/l Baseline 10.2 ± 0.8 10.0 ± 0.3 9.9 ± 1.9 10.4 ± 0.5 10.4 ± 1.4
  Before sepsis 9.6 ± 0.3 9.2 ± 1.4 9.8 ± 1.3 11.4 ± 1.0 9.4 ± 1.4
  12 h after sepsis 6.8 ± 0.7 10.9 ± 4.2 8.2 ± 1.2 15.4 ± 4.2**;+ 9.5 ± 0.2
  1. Data are presented as mean ± SD at baseline, 6 h after hemorrhagic shock and before sepsis induction (before sepsis) and 12 h after sepsis induction.
  2. BW, body weight; Cl, chloride; Crea, creatinine; K+ , potassium; Na, sodium.
  3. * P ≤ 0.01 vs. 6% HES130, RAc and SHAM; ** P ≤ 0.05 vs. RAc; + P ≤ 0.05 vs. 6% HES130; ‡ P ≤ 0.05 vs. SHAM; ║ P ≤ 0.05 vs. 10% HES200.