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Table 3 Measured and calculated parameters of oxygenation, hemodynamics, inflammation and acid-base metabolism

From: Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study

  

6% HES 130

10% HES 200

RAc

4% gelatin

SHAM

ITBV, ml/kgBW

Baseline

21 ± 4

22 ± 4

23 ± 2

23 ± 4

23 ± 1

 

Before sepsis

22 ± 2

25 ± 5

23 ± 1

25 ± 1

24 ± 2

 

12 h after sepsis

24 ± 4

22 ± 5

22 ± 3

26 ± 2

24 ± 1

DO 2 , ml/min/kgBW

Baseline

12.9 ± 2.5

14.6 ± 1.6

13.5 ± 1.4

13.2 ± 1.2

14.7 ± 0.8

 

Before sepsis

14.0 ± 3.1

12.5 ± 2.1

14.2 ± 1.2

15.0 ± 4.2

17.6 ± 0.6

 

12 h after sepsis

17.7 ± 3.0

17.8 ± 7.8

15.3 ± 3.3

14.0 ± 2.5

15.4 ± 1.8

OE %

Baseline

39 ± 8

34 ± 2

36 ± 5

33 ± 6

31 ± 8

 

Before sepsis

31 ± 15

32 ± 5

38 ± 6

30 ± 3

31 ± 5

 

12 h after sepsis

37 ± 6

48 ± 8 ‡

35 ± 9

48 ± 10 ‡

27 ± 6

VO 2 ml/min kgBW

Baseline

5.3 ± 1.0

5.3 ± 0.4

5.2 ± 1.2

4.4 ± 0.6

4.8 ± 1.2

 

Before sepsis

4.2 ± 1.8

4.7 ± 0.8

6.1 ± 2.0

4.5 ± 1.3

5.7 ± 0.6

 

12 h after sepsis

7.4 ± 2.5

8.7 ± 4.5

5.2 ± 1.1

7.1 ± 1.8

4.2 ± 0.6

SvO 2 , %

Baseline

65 ± 7

69 ± 2

67 ± 3

69 ± 7

71 ± 7

 

Before sepsis

74 ± 13

69 ± 7

68 ± 8

70 ± 7

70 ± 7

 

12 h after sepsis

62 ± 12

46 ± 9 ‡

60 ± 14

46 ± 12 ‡

75 ± 4

pHa

Baseline

7.49 ± 0.04

7.50 ± 0.03

7.50 ± 0.05

7.50 ± 0.01

7.53 ± 0.02

 

Before sepsis

7.54 ± 0.03

7.51 ± 0.02

7.51 ± 0.04

7.52 ± 0.02

7.52 ± 0.03

 

12 h after sepsis

7.48 ± 0.04

7.27 ± 0.12 *

7.47 ± 0.07

7.38 ± 0.01

7.49 ± 0.02

BE, mmol/l

Baseline

6 ± 2

6 ± 1

7 ± 3

7 ± 1

7 ± 1

 

Before sepsis

8 ± 1

7 ± 1

8 ± 2

9 ± 1

7 ± 1

 

12 h after sepsis

6 ± 1

-3 ± 5 *

7 ± 3

4 ± 6

7 ± 1

PaCO 2 , mm Hg

Baseline

39 ± 3

38 ± 3

40 ± 3

39 ± 2

38 ± 2

 

Before sepsis

36 ± 3

38 ± 2

39 ± 2

39 ± 2

38 ± 3

 

12 h after sepsis

40 ± 6

46 ± 5

43 ± 5

46 ± 6

38 ± 2

Interleukin 10, pg/ml

Baseline

-

-

-

-

-

 

Before sepsis

-

-

-

-

-

 

12 h after sepsis

88 ± 197

411 ± 245*

14 ± 31

296 ± 95

0 ± 0

  1. Data are presented as mean ± SD at baseline, 6 h after hemorrhagic shock and before sepsis induction (before sepsis) and 12 h after sepsis induction. BW, body weight; DO2, systemic oxygen delivery; HES, hydroxyethylstarch; ITBV, intrathoracic blood volume; OE, oxygen extraction ratio; PaCO2, arterial CO2; pHa, arterial pH; BE, base excess; SvO2, mixed venous oxygen saturation; VO2, oxygen consumption. * P ≤ 0.05 vs. 6% HES130, RAc and SHAM; ‡ P ≤ 0.05 vs. SHAM.
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