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Table 3 Measured and calculated parameters of oxygenation, hemodynamics, inflammation and acid-base metabolism

From: Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study

   6% HES 130 10% HES 200 RAc 4% gelatin SHAM
ITBV, ml/kgBW Baseline 21 ± 4 22 ± 4 23 ± 2 23 ± 4 23 ± 1
  Before sepsis 22 ± 2 25 ± 5 23 ± 1 25 ± 1 24 ± 2
  12 h after sepsis 24 ± 4 22 ± 5 22 ± 3 26 ± 2 24 ± 1
DO 2 , ml/min/kgBW Baseline 12.9 ± 2.5 14.6 ± 1.6 13.5 ± 1.4 13.2 ± 1.2 14.7 ± 0.8
  Before sepsis 14.0 ± 3.1 12.5 ± 2.1 14.2 ± 1.2 15.0 ± 4.2 17.6 ± 0.6
  12 h after sepsis 17.7 ± 3.0 17.8 ± 7.8 15.3 ± 3.3 14.0 ± 2.5 15.4 ± 1.8
OE % Baseline 39 ± 8 34 ± 2 36 ± 5 33 ± 6 31 ± 8
  Before sepsis 31 ± 15 32 ± 5 38 ± 6 30 ± 3 31 ± 5
  12 h after sepsis 37 ± 6 48 ± 8 ‡ 35 ± 9 48 ± 10 ‡ 27 ± 6
VO 2 ml/min kgBW Baseline 5.3 ± 1.0 5.3 ± 0.4 5.2 ± 1.2 4.4 ± 0.6 4.8 ± 1.2
  Before sepsis 4.2 ± 1.8 4.7 ± 0.8 6.1 ± 2.0 4.5 ± 1.3 5.7 ± 0.6
  12 h after sepsis 7.4 ± 2.5 8.7 ± 4.5 5.2 ± 1.1 7.1 ± 1.8 4.2 ± 0.6
SvO 2 , % Baseline 65 ± 7 69 ± 2 67 ± 3 69 ± 7 71 ± 7
  Before sepsis 74 ± 13 69 ± 7 68 ± 8 70 ± 7 70 ± 7
  12 h after sepsis 62 ± 12 46 ± 9 ‡ 60 ± 14 46 ± 12 ‡ 75 ± 4
pHa Baseline 7.49 ± 0.04 7.50 ± 0.03 7.50 ± 0.05 7.50 ± 0.01 7.53 ± 0.02
  Before sepsis 7.54 ± 0.03 7.51 ± 0.02 7.51 ± 0.04 7.52 ± 0.02 7.52 ± 0.03
  12 h after sepsis 7.48 ± 0.04 7.27 ± 0.12 * 7.47 ± 0.07 7.38 ± 0.01 7.49 ± 0.02
BE, mmol/l Baseline 6 ± 2 6 ± 1 7 ± 3 7 ± 1 7 ± 1
  Before sepsis 8 ± 1 7 ± 1 8 ± 2 9 ± 1 7 ± 1
  12 h after sepsis 6 ± 1 -3 ± 5 * 7 ± 3 4 ± 6 7 ± 1
PaCO 2 , mm Hg Baseline 39 ± 3 38 ± 3 40 ± 3 39 ± 2 38 ± 2
  Before sepsis 36 ± 3 38 ± 2 39 ± 2 39 ± 2 38 ± 3
  12 h after sepsis 40 ± 6 46 ± 5 43 ± 5 46 ± 6 38 ± 2
Interleukin 10, pg/ml Baseline - - - - -
  Before sepsis - - - - -
  12 h after sepsis 88 ± 197 411 ± 245* 14 ± 31 296 ± 95 0 ± 0
  1. Data are presented as mean ± SD at baseline, 6 h after hemorrhagic shock and before sepsis induction (before sepsis) and 12 h after sepsis induction. BW, body weight; DO2, systemic oxygen delivery; HES, hydroxyethylstarch; ITBV, intrathoracic blood volume; OE, oxygen extraction ratio; PaCO2, arterial CO2; pHa, arterial pH; BE, base excess; SvO2, mixed venous oxygen saturation; VO2, oxygen consumption. * P ≤ 0.05 vs. 6% HES130, RAc and SHAM; ‡ P ≤ 0.05 vs. SHAM.