Skip to main content

Table 1 Hemodynamic parameters and fluid balance

From: Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study

   6% HES 130 10% HES 200 RAc 4% gelatin SHAM
HR, bpm Baseline 93 ± 14 91 ± 10 89 ± 12 91 ± 9 98 ± 8
  Before sepsis 95 ± 5 96 ± 22 106 ± 20 92 ± 13 98 ± 11
  12 h after sepsis 140 ± 19 158 ± 19 ‡ 127 ± 18 151 ± 32 ‡ 93 ± 2
MAP, mm Hg Baseline 90 ± 1 91 ± 2 92 ± 2 91 ± 2 90 ± 1
  Before sepsis 91 ± 3 98 ± 8 91 ± 1 93 ± 4 91 ± 3
  12 h after sepsis 86 ± 11 70 ± 21 59 ± 5 71 ± 26 96 ± 7
CVP, mm Hg Baseline 7 ± 1 6 ± 1 7 ± 1 7 ± 1 6 ± 1
  Before sepsis 6 ± 2 9 ± 2 8 ± 1 8 ± 1 6 ± 1
  12 h after sepsis 12 ± 0 12 ± 0 12 ± 0 12 ± 0 12 ± 0
PAOP, mm Hg Baseline 8 ± 1 7 ± 1 8 ± 1 7 ± 1 7 ± 2
  Before sepsis 8 ± 2 8 ± 1 10 ± 2 9 ± 2 8 ± 1
  12 h after sepsis 11 ± 3 12 ± 1 11 ± 2 10 ± 1 12 ± 1
MPAP, mm Hg Baseline 15 ± 2 16 ± 3 19 ± 1 17 ± 2 18 ± 2
  Before sepsis 17 ± 2 20 ± 4 20 ± 1 19 ± 3 21 ± 1
  12 h after sepsis 33 ± 9 45 ± 3 *,§,‡ 26 ± 4 41 ± 3 §,‡ 21 ± 4
CO, ml/kgBW Baseline 102 ± 20 109 ± 17 110 ± 15 98 ± 8 110 ± 7
  Before sepsis 118 ± 13 133 ± 37 134 ± 28 137 ± 26 126 ± 19
  12 h after sepsis 171 ± 47 143 ± 48 137 ± 32 160 ± 42 120 ± 28
Hct, % Baseline 29 ± 1 31 ± 2 28 ± 2 30 ± 3 30 ± 1
  Before sepsis 26 ± 1 25 ± 4 26 ± 2 24 ± 4 30 ± 4
  12 h after sepsis 28 ± 4 30 ± 4 27 ± 3 25 ± 5 29 ± 4
COP, mm Hg Baseline 11.5 ± 0.9 11.4 ± 2.4 11.1 ± 2.2 11.2 ± 1.0 12.2 ± 1.1
  Before sepsis 11.8 ± 1.4 13.6 ± 1.7 9.9 ± 1.1 12.5 ± 0.9 10.9 ± 0.3
  12 h after sepsis 10.0 ± 1.7 14.6 ± 1.8 *;§;‡ 8.1 ± 1.5 15.1 ± 1.5 *;§;‡ 10.3 ± 0.4
Fluid input, ml/kg BW Baseline - - - - -
  Before sepsis 62 ± 11 45 ± 12 140 ± 41║ 62 ± 14 5 ± 7
  12 h after sepsis 213 ± 41 120 ± 35 556 ± 230║ 178 ± 36 110 ± 26
Fluid balance, ml/kg BW Baseline - - - - -
  Before sepsis 39 ± 3 28 ± 10 93 ± 25║ 45 ± 17 18 ± 11
  12 h after sepsis 149 ± 30 75 ± 33 335 ± 94║ 109 ± 28 68 ± 43
  1. Hemodynamics and Fluid balance in the five groups. Data are presented as mean ± SD at baseline, 6 h after hemorrhagic shock and before sepsis induction (before sepsis) and 12 h after sepsis induction. BW, body weight; CO, cardiac output; COP, colloid osmotic pressure; CVP, central venous pressure; Hct, hematocrit; HR, heart rate; MAP, mean arterial pressure; MPAP, mean pulmonary artery pressure; PAOP, pulmonary artery occlusion pressure.
  2. * P ≤ 0.05 vs. 6% HES130; § P ≤ 0.05 vs. RAc;;‡ P ≤ 0.05 vs. SHAM; ║P ≤ 0.05 vs. all other groups.