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Table 1 Hemodynamic parameters and fluid balance

From: Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study

  

6% HES 130

10% HES 200

RAc

4% gelatin

SHAM

HR, bpm

Baseline

93 ± 14

91 ± 10

89 ± 12

91 ± 9

98 ± 8

 

Before sepsis

95 ± 5

96 ± 22

106 ± 20

92 ± 13

98 ± 11

 

12 h after sepsis

140 ± 19

158 ± 19 ‡

127 ± 18

151 ± 32 ‡

93 ± 2

MAP, mm Hg

Baseline

90 ± 1

91 ± 2

92 ± 2

91 ± 2

90 ± 1

 

Before sepsis

91 ± 3

98 ± 8

91 ± 1

93 ± 4

91 ± 3

 

12 h after sepsis

86 ± 11

70 ± 21

59 ± 5

71 ± 26

96 ± 7

CVP, mm Hg

Baseline

7 ± 1

6 ± 1

7 ± 1

7 ± 1

6 ± 1

 

Before sepsis

6 ± 2

9 ± 2

8 ± 1

8 ± 1

6 ± 1

 

12 h after sepsis

12 ± 0

12 ± 0

12 ± 0

12 ± 0

12 ± 0

PAOP, mm Hg

Baseline

8 ± 1

7 ± 1

8 ± 1

7 ± 1

7 ± 2

 

Before sepsis

8 ± 2

8 ± 1

10 ± 2

9 ± 2

8 ± 1

 

12 h after sepsis

11 ± 3

12 ± 1

11 ± 2

10 ± 1

12 ± 1

MPAP, mm Hg

Baseline

15 ± 2

16 ± 3

19 ± 1

17 ± 2

18 ± 2

 

Before sepsis

17 ± 2

20 ± 4

20 ± 1

19 ± 3

21 ± 1

 

12 h after sepsis

33 ± 9

45 ± 3 *,§,‡

26 ± 4

41 ± 3 §,‡

21 ± 4

CO, ml/kgBW

Baseline

102 ± 20

109 ± 17

110 ± 15

98 ± 8

110 ± 7

 

Before sepsis

118 ± 13

133 ± 37

134 ± 28

137 ± 26

126 ± 19

 

12 h after sepsis

171 ± 47

143 ± 48

137 ± 32

160 ± 42

120 ± 28

Hct, %

Baseline

29 ± 1

31 ± 2

28 ± 2

30 ± 3

30 ± 1

 

Before sepsis

26 ± 1

25 ± 4

26 ± 2

24 ± 4

30 ± 4

 

12 h after sepsis

28 ± 4

30 ± 4

27 ± 3

25 ± 5

29 ± 4

COP, mm Hg

Baseline

11.5 ± 0.9

11.4 ± 2.4

11.1 ± 2.2

11.2 ± 1.0

12.2 ± 1.1

 

Before sepsis

11.8 ± 1.4

13.6 ± 1.7

9.9 ± 1.1

12.5 ± 0.9

10.9 ± 0.3

 

12 h after sepsis

10.0 ± 1.7

14.6 ± 1.8 *;§;‡

8.1 ± 1.5

15.1 ± 1.5 *;§;‡

10.3 ± 0.4

Fluid input, ml/kg BW

Baseline

-

-

-

-

-

 

Before sepsis

62 ± 11

45 ± 12

140 ± 41║

62 ± 14

5 ± 7

 

12 h after sepsis

213 ± 41

120 ± 35

556 ± 230║

178 ± 36

110 ± 26

Fluid balance, ml/kg BW

Baseline

-

-

-

-

-

 

Before sepsis

39 ± 3

28 ± 10

93 ± 25║

45 ± 17

18 ± 11

 

12 h after sepsis

149 ± 30

75 ± 33

335 ± 94║

109 ± 28

68 ± 43

  1. Hemodynamics and Fluid balance in the five groups. Data are presented as mean ± SD at baseline, 6 h after hemorrhagic shock and before sepsis induction (before sepsis) and 12 h after sepsis induction. BW, body weight; CO, cardiac output; COP, colloid osmotic pressure; CVP, central venous pressure; Hct, hematocrit; HR, heart rate; MAP, mean arterial pressure; MPAP, mean pulmonary artery pressure; PAOP, pulmonary artery occlusion pressure.
  2. * P ≤ 0.05 vs. 6% HES130; § P ≤ 0.05 vs. RAc;;‡ P ≤ 0.05 vs. SHAM; ║P ≤ 0.05 vs. all other groups.
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