Table 4 Patients' demographic and clinical characteristics according to mitochondrial DNA haplogroup
From: Survival and mitochondrial function in septic patients according to mitochondrial DNA haplogroup
Other haplogroups (n= 81) | JT haplogroup (n= 15) | P value | |
|---|---|---|---|
Gender male | 52 (64.2) | 8 (53.3) | 0.56 |
Age (years) | 59 (48 to 68) | 64 (54 to 81) | 0.11 |
Diabetes mellitus | 32 (39.5) | 4 (26.7) | 0.40 |
COPD | 9(11.1) | 1 (6.7) | 0.99 |
Ischemic heart disease | 6 (7.4) | 1 (6.7) | 0.99 |
Ischemic stroke | 3 (3.7) | 0 | 0.99 |
Site of infection | 0.96 | ||
Respiratory | 54 (66.7) | 8 (53.3) | |
Abdominal | 16 (19.8) | 5 (33.3) | |
Urinary | 3 (3.7) | 1 (6.7) | |
Skin | 5 (6.2) | 1 (6.7) | |
Endocarditis | 2 (2.5) | 0 | |
Others | 1 (1.2) | 0 | |
Microorganism responsible | |||
Unknown | 43 (53.1) | 6 (40.0) | 0.41 |
Gram-positive | 19 (23.5) | 5 (33.3) | 0.52 |
Gram-negative | 18 (22.2) | 4 (26.7) | 0.74 |
Fungi | 4 (4.9) | 0 | 0.99 |
Anaerobe | 1 (1.2) | 0 | 0.99 |
Bloodstream infection | 10 (12.3) | 3 (20.0) | 0.42 |
Empiric antimicrobial treatment | 0.81 | ||
Unknown if adequate due to negative cultures | 42 (51.9) | 7 (46.7) | |
Adequate | 32 (39.5) | 6 (40.0) | |
Unknown if adequate due to diagnosis by antigenuria | 6 (7.4) | 2 (13.3) | |
Inadequate | 1 (1.2) | 0 | |
β-lactamic more aminoglycoside | 17 (21.0) | 3 (20.0) | 0.30 |
β-lactamic more quinolone | 46 (56.8) | 6 (40.0) | 0.58 |
Mean blood pressure (mmHg) | 68 (63 to 71) | 69 (63 to 75) | 0.74 |
Septic shock | 70 (86.4) | 13 (86.7) | 0.99 |
Norepinephrine | 70 (86.4) | 13 (86.7) | 0.99 |
Norepinephrine dose (μg/kg/minute) | 0.5 (0.3 to 0.8) | 0.5 (0.4 to 0.9) | 0.75 |
Dobutamine | 6 (7.4) | 1 (6.7) | 0.99 |
Dobutamine dose (μg/kg/minute) | 6.0 (5.0 to 8.0) | 5.0 | 0.57 |
PaO2/FIO2 ratio | 160 (102 to 265) | 138 (84 to 197) | 0.98 |
Creatinine (mg/dl) | 1.20 (0.70 to 2.00) | 2.05 (1.10 to 3.07) | 0.35 |
Bilirubin (mg/dl) | 1.00 (0.55 to 2.30) | 0.92 (0.48 to 1.44) | 0.54 |
Leukocytes (×103/mm3) | 12.2 (5.4 to 19.9) | 16.4 (8.5 to 25.9) | 0.82 |
Lactic acid (mmol/l) | 2.20 (1.30 to 4.37) | 3.80 (1.70 to 4.65) | 0.20 |
Platelets (×103/mm3) | 180 (89 to 266) | 120 (43 to 193) | 0.28 |
INR | 1.32 (1.11 to 1.56) | 1.24 (1.15 to 1.67) | 0.35 |
aPTT (seconds) | 33 (29 to 42) | 36 (26 to 49) | 0.30 |
APACHE II score | 20 (16 to 25) | 21 (18 to 23) | 0.98 |
SOFA score | 9 (7 to 12) | 9 (8 to 12) | 0.78 |
Survivors at 180 days | 43 (53.1) | 11 (73.3) | 0.17 |
Survivors at 30 days | 50 (61.7) | 13 (86.7) | 0.08 |