Skip to main content

Table 1 Hepatic necrosis at 24 and 48 hours after acetaminophen administration

From: Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose

Animal groups

24 hours

48 hours

Saline (2 to 48 hours)

58.4 ± 7.3

8.6 ± 1.5

Ethyl pyruvate (2 to 48 hours)

35.6 ± 4.6a

26.6 ± 3.3a

Saline (2 to 24 hours)

 

8.8 ± 1.5

Ethyl pyruvate (2 to 24 hours)

 

3.4 ± 0.3a

Saline (24 to 48 hours)

 

8.3 ± 1.2

Ethyl pyruvate (24 to 48 hours)

 

23.2 ± 4.2a

  1. Hepatic necrosis is expressed as a percentage. Acetaminophen dose was 350 mg/kg. Six mice were in each group. aP < 0.05 between the saline treatment and the ethyl pyruvate therapy.
Back to article page