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Table 7 Studies evaluating sFLT

From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review

Study Year N Population Standard criteria for SIRS/sepsis Association with sepsis Other outcomes
Schuetz et al., [52] 2011 161 Patients with hypotension: 69 sepsis, 35 cardiac, 12 hemorrhagic, 12 unknown Clinical classification based on clinical and microbiological data sFlt-1 higher in sepsis compared to non-sepsis (P < 0.05) SFlt-1 independently associated with sepsis after adjustment for age, sex, blood pressure and mortality (P = 0.03) with AUC 0.70 for discrimination of sepsis from non-sepsis  
Shapiro et al., [77] 2008 83 ED patients with septic shock (17), suspected infection without shock (66), and non-infected controls Suspected infection based on treating clinician sFLT levels elevated with worsening disease: non-infected, suspected infection without shock, septic shock (159, 386 and 551 ng/dL, respectively, P < 0.01) sFLT correlated with APACHE-II, SOFA scores upon presentation and at 24 h (P < 0.05 for all)
Shapiro et al., [51] 2010 221 ED patients with sepsis without organ dysfunction (71), severe sepsis without shock (66), septic shock (71), and non-infected controls (13) 1992 ACCP/SCCM [1] sFLT levels elevated in septic shock compared with non-infected controls (243 vs 41 ng/ml, P < 0.001) sFLT correlated with SOFA, APACHE-II, lactate; Predicted severe sepsis and mortality (AUC of 0.82 (95% CI 0.76 to 0.88), 0.91 (95% CI 0.87 to 0.95))
  1. ACCP, American College of Chest Physicians; ALI, Acute Lung Injury; APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, Acute Respiratory Distress Syndrome; ED, emergency department; MOF, Multiple Organ Failure; SAPS, Simplified Acute Physiology Score; SCCM, Society of Critical Care Medicine; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment