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Table 6 Studies evaluating VEGF

From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review

Study Year N Population Standard criteria for SIRS/sepsis Association with sepsis Other outcomes
Shapiro et al., [77] 2008 83 ED patients with septic shock (17), suspected infection without shock (66), and non-infected controls Suspected infection based on treating clinician VEGF levels higher in septic shock and infected patients without shock compared with non-infected controls (P < 0.01) VEGF correlated with APACHE-II score at presentation (P = 0.01)
Karlsson et al., [82] 2008 280 Septic ICU patients (250) and healthy controls (30) 1992 ACCP/SCCM [1] VEGF levels higher in severe sepsis compared with healthy controls at 0 and 72 h (P = 0.029, 0.003, respectively) VEGF lower in non-survivors at 0 and 72 h (P = 0.012, 0.009, respectively), no correlation with SOFA scores
Kumpers et al., [42] 2008 72 Medical ICU (43) and healthy controls (29) 2003 ACCP/SCCM [2] VEGF levels lower in non-septic and septic patients compared with healthy controls (P < 0.0001) No association with severity of sepsis
Van der Heijden et al., [45] 2008 112 Mechanically ventilated patients with sepsis (24) and without (88) 1992 ACCP/SCCM [1] VEGF levels higher in patients with sepsis than without sepsis (63.6 vs 20.7 pg/ml, P = 0.012) VEGF trended higher in patients compared with controls (P = 0.268); No association with incidence of ALI/ARDS
Van der Flier et al., [83] 2005 58 Severe sepsis (18) and healthy controls (40) 1992 ACCP/SCCM [1] VEGF levels elevated in sepsis compared with healthy controls (134 vs 55 pg/ml, P < 0.001) VEGF correlated with mortality (P = 0.018)
Yang et al., [101] 2011 101 81 pneumonia and septic shock 20 pneumonia without organ dysfunction 1992 ACCP/SCCM [1] VEGF levels lower in septic shock vs. pneumonia (P = 0.005) Day 1 VEGF did not discriminate survivors from non-survivors (P = 0.46)
Rafat et al., [84] 2007 62 Medical ICU with sepsis (32), without sepsis (15), and healthy controls (15) 1992 ACCP/SCCM [1] VEGF levels elevated in septic compared with non-septic patients (1,351 vs 477 pg/ml, P < 0.01) VEGF not correlated with mortality (P < 0.48)
  1. ACCP, American College of Chest Physicians; ALI, Acute Lung Injury; APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, Acute Respiratory Distress Syndrome; ED, emergency department; MOF, Multiple Organ Failure; SAPS, Simplified Acute Physiology Score; SCCM, Society of Critical Care Medicine; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment