Table 6 Studies evaluating VEGF
From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review
Study | Year | N | Population | Standard criteria for SIRS/sepsis | Association with sepsis | Other outcomes |
|---|---|---|---|---|---|---|
Shapiro et al., [77] | 2008 | 83 | ED patients with septic shock (17), suspected infection without shock (66), and non-infected controls | Suspected infection based on treating clinician | VEGF levels higher in septic shock and infected patients without shock compared with non-infected controls (P < 0.01) | VEGF correlated with APACHE-II score at presentation (P = 0.01) |
Karlsson et al., [82] | 2008 | 280 | Septic ICU patients (250) and healthy controls (30) | 1992 ACCP/SCCM [1] | VEGF levels higher in severe sepsis compared with healthy controls at 0 and 72 h (P = 0.029, 0.003, respectively) | VEGF lower in non-survivors at 0 and 72 h (P = 0.012, 0.009, respectively), no correlation with SOFA scores |
Kumpers et al., [42] | 2008 | 72 | Medical ICU (43) and healthy controls (29) | 2003 ACCP/SCCM [2] | VEGF levels lower in non-septic and septic patients compared with healthy controls (P < 0.0001) | No association with severity of sepsis |
Van der Heijden et al., [45] | 2008 | 112 | Mechanically ventilated patients with sepsis (24) and without (88) | 1992 ACCP/SCCM [1] | VEGF levels higher in patients with sepsis than without sepsis (63.6 vs 20.7 pg/ml, P = 0.012) | VEGF trended higher in patients compared with controls (P = 0.268); No association with incidence of ALI/ARDS |
Van der Flier et al., [83] | 2005 | 58 | Severe sepsis (18) and healthy controls (40) | 1992 ACCP/SCCM [1] | VEGF levels elevated in sepsis compared with healthy controls (134 vs 55 pg/ml, P < 0.001) | VEGF correlated with mortality (P = 0.018) |
Yang et al., [101] | 2011 | 101 | 81 pneumonia and septic shock 20 pneumonia without organ dysfunction | 1992 ACCP/SCCM [1] | VEGF levels lower in septic shock vs. pneumonia (P = 0.005) | Day 1 VEGF did not discriminate survivors from non-survivors (P = 0.46) |
Rafat et al., [84] | 2007 | 62 | Medical ICU with sepsis (32), without sepsis (15), and healthy controls (15) | 1992 ACCP/SCCM [1] | VEGF levels elevated in septic compared with non-septic patients (1,351 vs 477 pg/ml, P < 0.01) | VEGF not correlated with mortality (P < 0.48) |