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Table 5 Studies evaluating Endocan

From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review

Study Year N Population Standard Criteria for SIRS/Sepsis Association with sepsis Other outcomes
Scherpereel et al., [53] 2006 90 ICU patients with sepsis (63), SIRS (7), healthy controls (20) 1992 ACCP/SCCM [1] Higher in sepsis than SIRS or healthy controls (2.71 vs 0.77 and 0.68 ng/ml; P < 0.001);higher in septic shock than severe sepsis and uncomplicated sepsis (6.11 vs 1.97 and 1.95 ng/ml; P < 0.05, P < 0.02) Endocan on ICU admission higher in nonsurvivors than patients still alive after 10 days (6.98 vs 2.54 ng/ml; P < 0.01), using a cutoff of 6.2 ng/ml, sensitivity and specificity are 75% and 84% respectively.
Bechard et al., [23] 2000 28 Patients with septic shock (8), healthy controls (20) 1992 ACCP/SCCM [1] Higher in septic shock than healthy controls (7.815 vs 1.081 ng/ml; P = 0.0173)  
  1. ACCP, American College of Chest Physicians; ALI, Acute Lung Injury; APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, Acute Respiratory Distress Syndrome; ED, emergency department; MOF, Multiple Organ Failure; SAPS, Simplified Acute Physiology Score; SCCM, Society of Critical Care Medicine; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment