Table 10 Studies evaluating ADAMTS13
From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review
Study | Year | N | Population | Standard criteria for SIRS/sepsis | Association with sepsis | Other outcomes |
|---|---|---|---|---|---|---|
Claus et al., [89] | 2009 | 63 | ICU patients with severe sepsis (11), non-elective cardiac surgery (22), elective cardiac surgery as ICU controls (24), and post-exercise as healthy controls (6) | 1992 ACCP/SCCM [1] | ADAMTS13 activity lower in sepsis than ICU reference group (P < 0.001) | ADAMTS13 activity correlated with mortality (P < 0.05) |
Bockmeyer et al., [90] | 2008 | 57 | ICU patients with sepsis (11), non-elective cardiac surgery (22), and elective cardiac surgery as ICU controls (24) | Not specified | ADAMTS13 activity lower in sepsis than ICU controls (P < 0.01) | ADAMTS13 activity correlated with mortality (P < 0.01) |
Hovinga et al., [95] | 2007 | 80 | Medical and surgical ICU patients with severe sepsis or septic shock (40), and healthy controls (40) | 1992 ACCP/SCCM [1] | ADAMTS13 activity lower in sepsis than healthy controls (P < 0.001) | ADAMTS13 activity not correlated with disease severity, organ dysfunction, or mortality |
Martin et al., [91] | 2007 | 89 | ICU patients with severe sepsis (30), sepsis-unrelated organ failure (29), and healthy controls (30) | 1992 ACCP/SCCM [1] | ADAMTS13 activity lower in severe sepsis than sepsis-unrelated organ failure (P < 0.05) and healthy controls (P < 0.05) | ADAMTS13 activity correlated with APACHE II (r = -0.66, P < 0.0001), number of organ failures (r = -0.66, P < 0.0001), and mortality (P = 0.02 by log rank test) |