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Table 10 Studies evaluating ADAMTS13

From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review

Study Year N Population Standard criteria for SIRS/sepsis Association with sepsis Other outcomes
Claus et al., [89] 2009 63 ICU patients with severe sepsis (11), non-elective cardiac surgery (22), elective cardiac surgery as ICU controls (24), and post-exercise as healthy controls (6) 1992 ACCP/SCCM [1] ADAMTS13 activity lower in sepsis than ICU reference group (P < 0.001) ADAMTS13 activity correlated with mortality (P < 0.05)
Bockmeyer et al., [90] 2008 57 ICU patients with sepsis (11), non-elective cardiac surgery (22), and elective cardiac surgery as ICU controls (24) Not specified ADAMTS13 activity lower in sepsis than ICU controls (P < 0.01) ADAMTS13 activity correlated with mortality (P < 0.01)
Hovinga et al., [95] 2007 80 Medical and surgical ICU patients with severe sepsis or septic shock (40), and healthy controls (40) 1992 ACCP/SCCM [1] ADAMTS13 activity lower in sepsis than healthy controls (P < 0.001) ADAMTS13 activity not correlated with disease severity, organ dysfunction, or mortality
Martin et al., [91] 2007 89 ICU patients with severe sepsis (30), sepsis-unrelated organ failure (29), and healthy controls (30) 1992 ACCP/SCCM [1] ADAMTS13 activity lower in severe sepsis than sepsis-unrelated organ failure (P < 0.05) and healthy controls (P < 0.05) ADAMTS13 activity correlated with APACHE II (r = -0.66, P < 0.0001), number of organ failures (r = -0.66, P < 0.0001), and mortality (P = 0.02 by log rank test)
  1. ACCP, American College of Chest Physicians; ALI, Acute Lung Injury; APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, Acute Respiratory Distress Syndrome; ED, emergency department; MOF, Multiple Organ Failure; SAPS, Simplified Acute Physiology Score; SCCM, Society of Critical Care Medicine; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment