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Table 1 Studies evaluating angiopoietin-2

From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review

Study Year N Population Standard Criteria for SIRS/Sepsis Association with Sepsis Other Outcomes
Parikh et al., [43] 2006 51 ICU patients with sepsis (22) and hospitalized controls (29) 2003 ACCP/SCCM [2] Ang-2 higher in patients severe sepsis than patients with sepsis and controls (23.2 vs. 4.8 and 3.5 ng/mL respectively; P < 0.01)  
Van der Heijden et al., [45] 2008 112 Mechanically ventilated patients, with sepsis (24) and without (88) 1992 ACCP/SCCM [1] Ang-2 higher in patients with sepsis than without sepsis (4.1 vs. 0.4 ng/mL; P < 0.01) Higher Ang-2 associated with ALI/ARDS (P < 0.001) and higher in ARDS than in ALI (P > 0.001); Independently associated with the severity of pulmonary leak (r = 0.41; P = 0.014).
Orfanos et al., [38] 2007 61 ICU patients 1992 ACCP/SCCM [1] Ang-2 higher in severe sepsis compared to patients without SIRS or sepsis (P < 0.05 by analysis of variance) Ang-2 levels correlated with levels of circulating TNF (P < 0.05)
Giamarellos-Bourboulis et al., [40] 2008 60 Trauma patients admitted to ICU (54) and healthy controls (6) 2003 ACCP/SCCM [2] Ang-2 higher in sepsis and severe sepsis than in healthy controls, or trauma patients with sterile SIRS (P < 0.05); Predictive of sepsis/severe sepsis (P = 0.017, 0.002 respectively); Increases in serial Ang-2 predicted development of sepsis (P < 0.05) Ang-2 correlated with 28-day survival (P = 0.015)
Kumpers et al., [42] 2008 72 Patients admitted to medical ICU (43) and healthy controls (29) 2003 ACCP/SCCM [2] Ang-2 higher in septic patients than in patients without sepsis (16.5 vs. 2.8 ng/mL; P < 0.001); Not correlated with severity of sepsis (median Ang-2 16.5 vs. 28.1 ng/mL; P = 0.12); Ang-2 correlated with mortality (P = 0.001)
Davis et al., [44] 2010 124 Patients admitted to a mixed ICU 1992 ACCP/SCCM [1] Ang-2 higher in patients with severe sepsis compared to patients with sepsis without organ failure and non-septic controls (12.4 vs. 6.1 and 2.7 ng/mL, respectively; P < 0.0001). Ang-2 not predictive of 28-day mortality (P = 0.32)
Siner et al., [39] 2009 66 Patients admitted to ICU 1992 ACCP/SCCM [1] Ang-2 not correlated with severity of sepsis Ang-2 correlated with mortality (P = 0.02)
Ricciuto et al. [48] 2011 70 Patients with severe sepsis 1992 ACCP/SCCM [1]   Admission levels of Ang-2 and Ang-2/Ang-1 ratio were not associated with 28-day mortality Serially measured Ang-2 levels correlated directly with the MOD score (P = .003)
Ebihara et al. [49] 2011 25 25 patients treated with Polymyxin-B column hemoperfusion 11 developed ALI 1992 ACCP/SCCM [1]   Positive correlation between Ang-1 and PaO2/FiO2 ratio (r = 0.427; P < 0.001) Inverse correlation between Ang-2 and PaO2/FiO2 ratio (r = 0.302; P = 0.003)
Page et al., [50] 2011 37 16 invasive streptococcal infection and toxic shock 21 invasive steptococcal infection alone S. pyogenes isolated from normally sterile site and 2009 Consensus definition of streptococcal toxic shock Ang-2:Ang-1 ratio increased in Streptococcal Toxic Shock Syndrome compared to those with uncomplicated invasive streptococcal infection (P < 0.05)  
Kranidoti et al., [41] 2009 107 ICU patients with Ventilator Associated pneumonia (90) and healthy controls (17) 2003 ACCP/SCCM [1] Ang-2 higher in septic patients compared to healthy controls. (P < 0.001) Ang-2 correlated with mortality (P < 0.05); Ang-2 levels greater than 9.7 ng/mL associated with sepsis-related mortality (OR = 3.3; P = 0.033)
  1. ACCP, American College of Chest Physicians; ALI, Acute Lung Injury; APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, Acute Respiratory Distress Syndrome; ED, emergency department; MOF, Multiple Organ Failure; SAPS, Simplified Acute Physiology Score; SCCM, Society of Critical Care Medicine; SIRS, systemic inflammatory response syndrome; SOFA, Sequential Organ Failure Assessment