From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review
Study | Year | N | Population | Standard Criteria for SIRS/Sepsis | Association with Sepsis | Other Outcomes |
---|---|---|---|---|---|---|
Parikh et al., [43] | 2006 | 51 | ICU patients with sepsis (22) and hospitalized controls (29) | 2003 ACCP/SCCM [2] | Ang-2 higher in patients severe sepsis than patients with sepsis and controls (23.2 vs. 4.8 and 3.5 ng/mL respectively; P < 0.01) | Â |
Van der Heijden et al., [45] | 2008 | 112 | Mechanically ventilated patients, with sepsis (24) and without (88) | 1992 ACCP/SCCM [1] | Ang-2 higher in patients with sepsis than without sepsis (4.1 vs. 0.4 ng/mL; P < 0.01) | Higher Ang-2 associated with ALI/ARDS (P < 0.001) and higher in ARDS than in ALI (P > 0.001); Independently associated with the severity of pulmonary leak (r = 0.41; P = 0.014). |
Orfanos et al., [38] | 2007 | 61 | ICU patients | 1992 ACCP/SCCM [1] | Ang-2 higher in severe sepsis compared to patients without SIRS or sepsis (P < 0.05 by analysis of variance) | Ang-2 levels correlated with levels of circulating TNF (P < 0.05) |
Giamarellos-Bourboulis et al., [40] | 2008 | 60 | Trauma patients admitted to ICU (54) and healthy controls (6) | 2003 ACCP/SCCM [2] | Ang-2 higher in sepsis and severe sepsis than in healthy controls, or trauma patients with sterile SIRS (P < 0.05); Predictive of sepsis/severe sepsis (P = 0.017, 0.002 respectively); Increases in serial Ang-2 predicted development of sepsis (P < 0.05) | Ang-2 correlated with 28-day survival (P = 0.015) |
Kumpers et al., [42] | 2008 | 72 | Patients admitted to medical ICU (43) and healthy controls (29) | 2003 ACCP/SCCM [2] | Ang-2 higher in septic patients than in patients without sepsis (16.5 vs. 2.8 ng/mL; P < 0.001); Not correlated with severity of sepsis (median Ang-2 16.5 vs. 28.1 ng/mL; P = 0.12); | Ang-2 correlated with mortality (P = 0.001) |
Davis et al., [44] | 2010 | 124 | Patients admitted to a mixed ICU | 1992 ACCP/SCCM [1] | Ang-2 higher in patients with severe sepsis compared to patients with sepsis without organ failure and non-septic controls (12.4 vs. 6.1 and 2.7 ng/mL, respectively; P < 0.0001). | Ang-2 not predictive of 28-day mortality (P = 0.32) |
Siner et al., [39] | 2009 | 66 | Patients admitted to ICU | 1992 ACCP/SCCM [1] | Ang-2 not correlated with severity of sepsis | Ang-2 correlated with mortality (P = 0.02) |
Ricciuto et al. [48] | 2011 | 70 | Patients with severe sepsis | 1992 ACCP/SCCM [1] | Â | Admission levels of Ang-2 and Ang-2/Ang-1 ratio were not associated with 28-day mortality Serially measured Ang-2 levels correlated directly with the MOD score (P = .003) |
Ebihara et al. [49] | 2011 | 25 | 25 patients treated with Polymyxin-B column hemoperfusion 11 developed ALI | 1992 ACCP/SCCM [1] | Â | Positive correlation between Ang-1 and PaO2/FiO2 ratio (r = 0.427; P < 0.001) Inverse correlation between Ang-2 and PaO2/FiO2 ratio (r = 0.302; P = 0.003) |
Page et al., [50] | 2011 | 37 | 16 invasive streptococcal infection and toxic shock 21 invasive steptococcal infection alone | S. pyogenes isolated from normally sterile site and 2009 Consensus definition of streptococcal toxic shock | Ang-2:Ang-1 ratio increased in Streptococcal Toxic Shock Syndrome compared to those with uncomplicated invasive streptococcal infection (P < 0.05) | Â |
Kranidoti et al., [41] | 2009 | 107 | ICU patients with Ventilator Associated pneumonia (90) and healthy controls (17) | 2003 ACCP/SCCM [1] | Ang-2 higher in septic patients compared to healthy controls. (P < 0.001) | Ang-2 correlated with mortality (P < 0.05); Ang-2 levels greater than 9.7 ng/mL associated with sepsis-related mortality (OR = 3.3; P = 0.033) |