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Table 1 Results:

From: Selective phosphodiesterase type 5 inhibition improves responsiveness to inhaled nitric oxide in endotoxin-challenged rats

 

NO 4 ppm

NO 10 ppm

Decrease of PAP (mmHg)

-0.7 ± 0.1 (n = 6)

-1.0 ± 0.1- (n = 6)

Zaprinast (50 µg)

-1.9 ± 1.8* (n = 14)

-2.9 ± 1.3* (n = 4)

Sildenafil (10 ng)

-1.8 ± 1.1* (n = 6)

-2.4 ± 0.5* (n = 5)

  1. -P < 0.05 vs NO ppm and *P < 0.05 vs NO 4 ppm and NO 10 ppm, respectively; ANOVA.
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Critical Care

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