Table 1
From: Prevalence of pituitary disorders associated with traumatic brain injury: a systematic review
Hypopituitarism | GH | ACTH | TSH | Gonadal | ADH | |
|---|---|---|---|---|---|---|
Acute phase | ||||||
All studies, | 58.3% (32.3 to 76.1), | 28.7% (8.8 to 77.2), | 14.3% (0.7 to 45.7), | 9.4% (0 to 40.6), | 44.3% (7.7 to 91.7), | 12.6% (0 to 27.2), |
n (patients) | 6 (513) | 9 (784) | 11 (958) | 12 (837) | 10 (827) | 13 (1821) |
Low risk of bias, | 71.3% (52.9 to 76.1), | 36.8% (8.8 to 77.2), | 14.5% (0.7 to 23.6), | 10.1% (1.6 to 32.6), | 54.3% (23.5 to 80.0), | 18.8% (0 to 27.2), |
n (patients) | 3 (216) | 5 (389) | 4 (385) | 6 (523) | 5 (337) | 5 (739) |
+ moderate/severe, | 70.0% (52.9 to 74.3), | 36.1% (8.8 to 77.2), | 14.5% (0.7 to 23.6), | 5.2% (1.6 to 14.7), | 61.4% (23.5 to 80.0), | 23.8% (0 to 27.2), |
n (patients) | 2 (170) | 4 (321) | 4 (385) | 4 (406) | 3 (220) | 4 (303) |
Mid-term | ||||||
All studies, | 32.1% (8.9 to 56.4), | 14.8% (6.3 to 25.0), | 9.7% (0 to 50.0), | 4.3% (0 to 22.2), | 18.8% (0 to 66.7), | 3.8% (0 to 14.0), |
n (patients) | 9 (608) | 11 (643) | 12 (669) | 11 (629) | 15 (792) | 11 (691) |
Low risk of bias, | - | 12.1% (6.3 to 22.2), | 16.7% (4.2 to 50.0), | 6.1% (0 to 22.2), | 25.2% (0 to 56.3), | 11.2% (8.3 to 14.0), |
n (patients) | 5 (231) | 4 (215) | 5 (231) | 5 (218) | 2 (98) | |
+ moderate/severe, | - | 12.1% (6.32 to 22.2), | 16.7% (4.2 to 50.0), | 6.1% (0 to 22.2), | 25.2% (0 to 56.3), | 8.3% (-), |
n (patients) | 5 (231) | 4 (215) | 5 (231) | 5 (218) | 1 (48) | |
Long-term | ||||||
All studies, | 29.1% (0.9 to 73.3), | 15.0% (0 to 51.8), | 10.2% (0 to 64.4), | 6.3% (0 to 31.8), | 12.2% (0 to 50.0), | 2.7% (0 to 18.2), |
n (patients) | 19 (1418) | 27 (1966) | 26 (1782) | 25 (1698) | 25 (1798) | 17 (1108) |
Low risk of bias, | 31.1% (-), | 16.6% (7.2 to 28.0), | 6.8% (0 to 18.8), | 8.2% (1.0 to 20.0), | 12.9% (1.5 to 29.3), | 5.0% (0 to 6.9), |
n (patients) | 1 (45) | 8 (499) | 6 (369) | 10 (734) | 9 (707) | 3 (200) |
+ moderate/severe, | 31.1% (-), | 15.7% (7.2 to 21.7), | 7.3% (1.4 to 18.8), | 8.6% (1.0 to 20.0), | 12.7% (1.5 to 29.3), | 6.7% (6.3 to 6.9), |
n (patients) | 1 (45) | 5 (381) | 4 (301) | 7 (616) | 6 (589) | 2 (150) |