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Table 5 Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and INO plus dobutamine in severe chronic obstructive pulmonary disease (COPD) (11 patients)

From: Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension

 

Baseline

INO

Dobutamine

INO+Dobutamine

Cardiac index (l/min/m2)

3.2 ± 1.9

3.2 ± 2.3

5.0 ± 2.7

4.7 ± 2.4**

Heart rate (beats/min)

83 ± 28

83 ± 30

104 ± 28

101 ± 29*

SVI (ml/m2)

38 ± 11

39 ± 13

49 ± 18

47 ± 19

CVP (mmHg)

2.5 ± 3

2.5 ± 3.1

2.0 ± 1.8

2.0 ± 2.0

MPAP (mmHg)

23 ± 7

21 ± 7

25 ± 8

24 ± 9

PAOP (mmHg)

6.6 ± 4.5

6.0 ± 4.9

5.3 ± 4.7

5.0 ± 4.0

MPAP-PAOP (mmHg)

16 ± 8

15 ± 6

19 ± 7*

19 ± 9

PVRI (dyne/s/cm5/m2)

671 ± 277

601 ± 247

471 ± 262*

492 ± 300*

MAP (mmHg)

87 ± 12

89 ± 11

91 ± 9

93 ± 12

SVRI (dyne/s/cm5/m2)

2524 ± 873

2625 ± 1012

1654 ± 541

1824 ± 683**

Qs/Qt (%)

23 ± 11

15 ± 6

28 ± 10*

17 ± 5

PaO2/FiO2 (mmHg)

322 ± 115

442 ± 103*

310 ± 93

419 ± 90*

PaCO2 (mmHg)

45 ± 11

44 ± 11

43 ± 11

45 ± 13

  1. *P < 0.05; **P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index.