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Table 5 Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and INO plus dobutamine in severe chronic obstructive pulmonary disease (COPD) (11 patients)

From: Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension

  Baseline INO Dobutamine INO+Dobutamine
Cardiac index (l/min/m2) 3.2 ± 1.9 3.2 ± 2.3 5.0 ± 2.7 4.7 ± 2.4**
Heart rate (beats/min) 83 ± 28 83 ± 30 104 ± 28 101 ± 29*
SVI (ml/m2) 38 ± 11 39 ± 13 49 ± 18 47 ± 19
CVP (mmHg) 2.5 ± 3 2.5 ± 3.1 2.0 ± 1.8 2.0 ± 2.0
MPAP (mmHg) 23 ± 7 21 ± 7 25 ± 8 24 ± 9
PAOP (mmHg) 6.6 ± 4.5 6.0 ± 4.9 5.3 ± 4.7 5.0 ± 4.0
MPAP-PAOP (mmHg) 16 ± 8 15 ± 6 19 ± 7* 19 ± 9
PVRI (dyne/s/cm5/m2) 671 ± 277 601 ± 247 471 ± 262* 492 ± 300*
MAP (mmHg) 87 ± 12 89 ± 11 91 ± 9 93 ± 12
SVRI (dyne/s/cm5/m2) 2524 ± 873 2625 ± 1012 1654 ± 541 1824 ± 683**
Qs/Qt (%) 23 ± 11 15 ± 6 28 ± 10* 17 ± 5
PaO2/FiO2 (mmHg) 322 ± 115 442 ± 103* 310 ± 93 419 ± 90*
PaCO2 (mmHg) 45 ± 11 44 ± 11 43 ± 11 45 ± 13
  1. *P < 0.05; **P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index.