Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension

Table 4 Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and INO plus dobutamine in cystic fibrosis (8 patients)

	Baseline	INO	Dobutamine	INO+Dobutamine
Cardiac index (l/min/m²)	3.6 ± 0.6	3.6 ± 0.5	5.1± 0.6	4.7± 0.5^**
Heart rate (beats/min)	90 ± 26	90 ± 25	102 ± 22	104 ± 18
SVI (ml/m²)	43 ± 12	43 ± 10	52 ± 10	47 ± 7
CVP (mmHg)	1.4 ± 1.9	1.6 ± 2.1	1.9 ± 2.4	1.4 ± 2
MPAP (mmHg)	24 ± 4	22 ± 3	26 ± 5	24 ± 3
PAOP (mmHg)	5.7 ± 2.7	6.5 ± 3.5	6.2 ± 3.3	5.6 ± 2.6
MPAP-PAOP (mmHg)	18 ± 2	16 ± 2^*	20 ± 2	18 ± 3
PVRI (dyne/s/cm⁵/m²)	591 ± 148	548 ± 140	448 ± 96^*	460 ± 98^*
MAP (mmHg)	83 ± 15	83 ± 11	87 ± 13	89 ± 13
SVRI (dyne/s/cm⁵/m²)	1826 ± 261	1825 ± 230	1371 ± 193	1495 ± 197^**
Q_s/Q_t (%)	20 ± 7	17 ± 4	30 ± 6^*	22 ± 5
PaO₂/FiO₂ (mmHg)	276 ± 56	350 ± 48^*	260 ± 56	319 ± 65
PaCO₂ (mmHg)	54 ± 11	55 ± 11	54 ± 12	53 ± 12

^*P < 0.05; ^**P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index.

ISSN: 1364-8535