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Table 3 Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and INO plus dobutamine in bronchiectasis (9 patients)

From: Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension

  Baseline 1 INO Dobutamine INO+Dobutamine
Cardiac index (l/min/m2) 3.9 ± 1.9 3.8 ± 1.5 5.6 ± 1.4 4.5 ± 0.3
Heart rate (beats/min) 87 ± 17 85 ± 12 115 ± 25 114 ± 23*
SVI (ml/m2) 43 ± 15 43 ± 13 53 ± 27 42 ± 12
CVP (mmHg) 3.2 ± 2.8 4 ± 3 3.2 ± 2.7 3.2 ± 3.9
MPAP (mmHg) 33 ± 16 28 ± 14 37 ± 17 36 ± 17
PAOP (mmHg) 9.4 ± 2 7.8 ± 1 12.5 ± 5 9.2 ± 3.3
MPAP-PAOP (mmHg) 24 ± 15 20 ± 14 24 ± 17 27 ± 18
PVRI (dyne/s/cm5/m2) 781 ± 424 662 ± 355 569 ± 321 641 ± 335*
MAP (mmHg) 86 ± 10 88 ± 9 90 ± 14 79 ± 11
SVRI (dyne/s/cm5/m2) 1919 ± 684 1974 ± 712 1272 ± 256 1391 ± 237*
Qs/Qt (%) 19 ± 5 11 ± 4* 24 ± 7 15 ± 12
PaO2/FiO2 (mmHg) 366 ± 113 448 ± 92 344 ± 95 435 ± 115
PaCO2 (mmHg) 51 ± 20 52 ± 23 53 ± 24 56 ± 23
  1. *P < 0.05; **P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index.