Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension

Table 3 Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and INO plus dobutamine in bronchiectasis (9 patients)

	Baseline 1	INO	Dobutamine	INO+Dobutamine
Cardiac index (l/min/m²)	3.9 ± 1.9	3.8 ± 1.5	5.6 ± 1.4	4.5 ± 0.3
Heart rate (beats/min)	87 ± 17	85 ± 12	115 ± 25	114 ± 23^*
SVI (ml/m²)	43 ± 15	43 ± 13	53 ± 27	42 ± 12
CVP (mmHg)	3.2 ± 2.8	4 ± 3	3.2 ± 2.7	3.2 ± 3.9
MPAP (mmHg)	33 ± 16	28 ± 14	37 ± 17	36 ± 17
PAOP (mmHg)	9.4 ± 2	7.8 ± 1	12.5 ± 5	9.2 ± 3.3
MPAP-PAOP (mmHg)	24 ± 15	20 ± 14	24 ± 17	27 ± 18
PVRI (dyne/s/cm⁵/m²)	781 ± 424	662 ± 355	569 ± 321	641 ± 335^*
MAP (mmHg)	86 ± 10	88 ± 9	90 ± 14	79 ± 11
SVRI (dyne/s/cm⁵/m²)	1919 ± 684	1974 ± 712	1272 ± 256	1391 ± 237^*
Q_s/Q_t (%)	19 ± 5	11 ± 4^*	24 ± 7	15 ± 12
PaO₂/FiO₂ (mmHg)	366 ± 113	448 ± 92	344 ± 95	435 ± 115
PaCO₂ (mmHg)	51 ± 20	52 ± 23	53 ± 24	56 ± 23

^*P < 0.05; ^**P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index.

ISSN: 1364-8535