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Table 2 Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and to dobutamine plus INO in all patients. The baseline values presented are the means of the three baseline studies assessed before each challenge

From: Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension

  Baseline INO Dobutamine INO+Dobutamine
Cardiac index (l/min/m2) 3.2 ± 1.2 3.2 ± 1.2 4.7 ± 1.2** 4.4 ± 1.2**
Heart rate (beats/min) 87 ± 18 86 ± 17 113 ± 18** 109 ± 19**
SVI (ml/m2) 36 ± 10 37 ± 9 44 ± 16** 41 ± 11**
CVP (mmHg) 2.5 ± 2.8 3.1 ± 3.1 2.4 ± 2.5 2.7 ± 2.9
MPAP (mmHg) 26 ± 10 24 ± 9** 31 ± 15* 27 ± 12
PAOP (mmHg) 7 ± 3 7.4 ± 4 8 ± 4 7 ± 3
MPAP-PAOP (mmHg) 19 ± 10 17 ± 9** 23 ± 14 20 ± 11
PVRI (dyne/s/cm5/m2) 535 ± 285 477 ± 293* 441 ± 331 416 ± 265**
MAP (mmHg) 86 ± 11 87 ± 10 86 ± 10 85 ± 10
SVRI (dyne/s/cm5/m2) 2363 ± 764 2348 ± 786 1346 ± 243** 1614 ± 439**
Qs/Qt (%) 23 ± 5 20 ± 5* 26 ± 5** 25 ± 7
PaO2/FiO2 (mmHg) 327 ± 90 418 ± 104** 296 ± 90* 390 ± 111**
PaCO2 (mmHg) 51 ± 12 52 ± 12 51 ± 13 50 ± 13
  1. *P < 0.05; **P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index.