Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension

Table 2 Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and to dobutamine plus INO in all patients. The baseline values presented are the means of the three baseline studies assessed before each challenge

	Baseline	INO	Dobutamine	INO+Dobutamine
Cardiac index (l/min/m²)	3.2 ± 1.2	3.2 ± 1.2	4.7 ± 1.2^**	4.4 ± 1.2^**
Heart rate (beats/min)	87 ± 18	86 ± 17	113 ± 18^**	109 ± 19^**
SVI (ml/m²)	36 ± 10	37 ± 9	44 ± 16^**	41 ± 11^**
CVP (mmHg)	2.5 ± 2.8	3.1 ± 3.1	2.4 ± 2.5	2.7 ± 2.9
MPAP (mmHg)	26 ± 10	24 ± 9^**	31 ± 15^*	27 ± 12
PAOP (mmHg)	7 ± 3	7.4 ± 4	8 ± 4	7 ± 3
MPAP-PAOP (mmHg)	19 ± 10	17 ± 9^**	23 ± 14	20 ± 11
PVRI (dyne/s/cm⁵/m²)	535 ± 285	477 ± 293^*	441 ± 331	416 ± 265^**
MAP (mmHg)	86 ± 11	87 ± 10	86 ± 10	85 ± 10
SVRI (dyne/s/cm⁵/m²)	2363 ± 764	2348 ± 786	1346 ± 243^**	1614 ± 439^**
Q_s/Q_t (%)	23 ± 5	20 ± 5^*	26 ± 5^**	25 ± 7
PaO₂/FiO₂ (mmHg)	327 ± 90	418 ± 104^**	296 ± 90^*	390 ± 111^**
PaCO₂ (mmHg)	51 ± 12	52 ± 12	51 ± 13	50 ± 13

^*P < 0.05; ^**P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index.

ISSN: 1364-8535