| Delirium (n= 50) | Nondelirium (n= 50) | Differences Pvalue | ||
---|---|---|---|---|---|
Proinflammatory cytokines | Â | Â | Â | ||
TNF-α (pg/ml) | 11 | [7-14] | 8 | [5-13] | 0.02 |
IL-1β (pg/ml) | 3 | [3-6] | 3 | [3-7] | 0.63 |
IL-6 (pg/ml) | 61 | [37-113] | 37 | [23-81] | 0.01 |
IL-8 (pg/ml) | 29 | [20-39] | 17 | [9-26] | < 0.0001 |
IL-17 (pg/ml) | 3 | [3-4] | 3 | [3-4] | 0.17 |
IL-18 (pg/ml) | 99 | [74-161] | 86 | [70-120] | 0.11 |
MIF (pg/ml) | 418 | [300-724] | 257 | [157-576] | 0.02 |
Antiinflammatory cytokines | Â | Â | Â | ||
IL-1ra (pg/ml) | 36 | [17-68] | 21 | [13-33] | 0.001 |
IL-10 (pg/ml) | 29 | [16-51] | 18 | [9-39] | 0.01 |
Chemotactic cytokines | Â | Â | Â | Â | Â |
MCP-1 (pg/ml) | 372 | [248-589] | 239 | [179-325] | < 0.0001 |
Defensin | Â | Â | Â | Â | Â |
HNP (μg/ml) | 0.06 | [0.03-0.12] | 0.06 | [0.03-0.10] | 0.89 |
Markers of inflammation | Â | Â | Â | ||
CRP (mg/ml) | 56 | [35-114] | 47 | [32-84] | 0.11 |
Procalcitonin (ng/ml) | 0.35 | [0.17-1.68] | 0.14 | [0.07-0.36] | < 0.0001 |
Stress-response hormone | Â | Â | Â | ||
Cortisol (μmol/L) | 0.51 | [0.31-0.97] | 0.35 | [0.09-0.62] | 0.006 |
Brain-specific proteins | Â | Â | Â | Â | Â |
S100-β (pg/ml) | 132 | [100-294] | 135 | [90-219] | 0.40 |
Tau (pg/ml) | 41 | [24-91] | 32 | [17-56] | 0.07 |
Ratio tau/Aβ1-42 | 1.14 | [0.62-2.71] | 0.95 | [0.47-1.69] | 0.10 |
Aβ1-42 (pg/ml) | 36 | [29-47] | 36 | [30-41] | 0.70 |
Aβ1-40 (pg/ml) | 156 | [129-225] | 146 | [113-163] | 0.05 |
Ratio Aβ1-42/40 | 0.23 | [0.20-0.27] | 0.25 | [0.23-0.30] | 0.006 |
AβN-42 (pg/ml) | 31 | [23-40] | 29 | [24-36] | 0.65 |
AβN-40 (pg/ml) | 222 | [167-276] | 178 | [146-220] | 0.02 |
Ratio Aβ N-42/40 | 0.15 | [0.12-0.17] | 0.17 | [0.14-0.19] | 0.04 |
Ratio Aβ1-42/N-42 | 1.26 | [1.03-1.34] | 1.29 | [1.10-1.40] | 0.48 |
Ratio Aβ1-40/N-40 | 0.78 | [0.69-0.85] | 0.80 | [0.73-0.92] | 0.28 |