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Table 2 Study interventions and clinical management received in the pre-operative, intra-operative and post-operative periods

From: A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery - the FOCCUS study

 

Fluid loading (n= 57)

Fluid control (n= 54)

 
 

Median (IQR)

Min, Max

Median (IQR)

Min, Max

P -value

Pre-operative fluid load* (ml)

1,875

(1,375, 2,025)

0, 2,950

0

(0, 0)

0, 1,415

< 0.001

Additional IV fluid load in: bowel preparation

0

 

0

  

patients (ml)

(0, 0)

0, 1,475

(0, 693)

0, 1,500

0.397

Total pre-operative fluid (ml)

1,975

(1,500, 2,275)

0, 4,130

0

(0, 721)

0, 1,500

0.000

Intra-operative fluid (ml)

2,200

(1,738, 3,500)

970, 7,000

3,000

(2,075, 3,808)

1,000, 6,685

0.078

Total pre and intra-operative fluid (ml)

4,186

(3,500, 5,527)

2,000, 9,543

3,000

(2,500, 4,050)

1,000, 7,885

< 0.001

Total fluid in 24

hours after surgery (ml)

3,512

(2,975, 4,356)

1,064, 5,900

3,770

(3,084, 4,434)

1,875, 6,644

0.307

Total fluid between 24

and 48 hours after surgery (ml)

3,000

(2,340, 3,416)

1,320, 6,348

3,219

(2,484, 3,942)

1,650, 4,850

0.235

Initial post-operative care location (treatment delivered)

n (%)

n (%)

 

   ICU care

14 (25%)

7 (13%)

 

   HDU care

35 (64%)

46 (85%)

 

   Ward care

6 (11%)

1 (2%)

 
 

Median (IQR)

Min, Max

Median (IQR)

Min, Max

P -value

Total time in ICU after

surgery (hrs)

0

(0, 7.2)

0, 701.2

0

(0, 0)

0, 331.0

0.327

Total time in HDU after

surgery (hrs)

71.5

(44.0, 120.2)

0, 580.3

92.9

(67.4, 148.2)

0, 617.4

0.028

Total time in Ward after surgery (hrs)

122.5

(89.3, 216.5)

22.3, 1198.5

164.5

(90.9, 303.8)

5.0, 3080.0

0.204

  1. Hrs, hours; IQR, Interquartile range; ml: millilitres.
  2. *Two participants in the fluid loading group were treated as part of the trial but received no pre-operative fluid loading and four participants in the fluid control group received pre-operative fluid loading.